REFERENCES

  1. Amgen Canada Inc. Vectibix (panitumumab for injection) Product Monograph. October 25, 2021.
  2. Douillard JY, et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010;28(31):4697-4705.
  3. Douillard JY, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023-1034.
  4. Amado RG, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol.
    2008;26(10):1626-1634.
  5. Van Cutsem E, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007;25(13):1658-1664.
  6. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer. 2023.
  7. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Rectal Cancer. 2023.
  8. Melosky B, et al. Management of skin rash during EGFR-targeted monoclonal antibody treatment for gastrointestinal malignancies: Canadian recommendations. Curr Oncol. 2009;16(1):16-26.
  9. Lacouture ME, et al. Clinical practice guidelines for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities.
    Support Care Cancer. 2011;19(8):1079-1095.
  10. Merck Manual. Hirsutism and Hypertrichosis. 2022. Available at: https://www.merckmanuals.com/en-ca/professional/dermatologic-disorders/hair-disorders/hirsutism-and-hypertrichosis. Retrieved May 17, 2023.
  11. Cipher Pharmaceuticals Inc. VANIQA Product Monograph. April 12, 2019.
  12. National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) v5.0. 2017.
  13. Cancer Care Alberta. Clinical Practice Guidelines: Prevention and Treatment of Acneiform Rash in Patients Treated with EGFR Inhibitor Therapies. Nov. 2020.