@font-face {
    font-family: 'Futura PT';
    src: local('Futura PT Light'), local('Futura-PT-Light'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/futura-pt-light/FuturaPT-Light2.woff2') format('woff2'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/futura-pt-light/FuturaPT-Light1.woff') format('woff'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/futura-pt-light/FuturaPT-Light.ttf') format('truetype');
    font-weight: 300;
    font-style: normal;
}

@font-face {
    font-family: 'Futura PT';
    src: local('Futura PT Book'), local('Futura-PT-Book'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/book/FuturaPT-Book2.woff2') format('woff2'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/book/FuturaPT-Book1.woff') format('woff'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/book/FuturaPT-Book.ttf') format('truetype');
    font-weight: 400;
    font-style: normal;
}

@font-face {
    font-family: 'Futura PT';
    src: local('Futura PT Medium'), local('Futura-PT-Medium'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/medium/FuturaPT-Medium2.woff2') format('woff2'),
        url('/sitecore/media library/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/medium/FuturaPT-Medium1.woff') format('woff'),
        url('/-/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Vectibix/fonts/futura-pt/medium/FuturaPT-Medium.ttf') format('truetype');
    font-weight: 500;
    font-style: normal;
}

body {
    font-family: 'Futura PT';
    font-weight: 400;
    font-style: normal;
    color: #6d6e71;
    font-size: 16px;
    line-height: 1.5;
    margin: 0;
    overflow-y: scroll !important;
    overflow-x: hidden !important;
}

/* .download-btn-select-all, .download-section {
   max-width: 1280px;
   margin: 0 auto;
} */
.download-btn-select-all,
.download-a-copy-section,
.download-section,
#main-cnt,
.inner-page-banner>div.row.component.column-splitter,
.component.carousel,
#footer-top>.component-content,
div#moa-md-sec,
#cnt-custom,
.cnt-custom,
#footer .component.container.col-12,
.banner .quantum-banner__text,
div#video-bottom-text,
.inner-page-banner .quantum-banner__text,
.dosing-c-border,
.download-btn-select-all,
.download-section,
ul.tabs-heading,
.tabs-container,
#patient-resources,
#moa-footer .component-content {
    max-width: 1280px;
    margin: 0 auto;
}

.download-btn-select-all,
.download-section,
.download-a-copy-section {
    max-width: 1250px;
}

form#patient-resources-obu-kyp {
    position: absolute;
    max-width: 1100px;
    background: #fff;
    padding: 2rem;
    margin: auto;
    display: block;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    width: 90%;
}

.popup-title.cnt-frm {
    align-items: center;
}

.model-popup-patient-resources {
    position: fixed;
    width: 100vw;
    height: 100vh;
    background: rgb(0 0 0 / 65%);
    z-index: 999;
    display: block;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    width: 100%;
    margin: auto;
    display: none;
}

#patient-resources-obu-kyp input,
#patient-resources-obu-kyp textarea {
    border: 1px solid #BEC3C5;
    padding: 0.6rem;
    border-radius: 3px;
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1rem;
}

textarea#email-body {
    resize: vertical;
    height: 90px;
}

.email-details {
    display: flex;
    flex-wrap: wrap;
    justify-content: space-between;
    margin: 2rem 0;
}

.frm-td {
    display: grid;
    margin-bottom: 1rem;
}

.hidden-fld {
    display: none;
}

.frm-td label {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1rem;
    line-height: 1.5;
    color: #212426;
}

.contacts-from-td.frm-tr {
    width: 100%;
    flex: 0 0 100%;
}

.contacts-from-td {
    flex: 0 0 48%;

}

small.error-msg {
    display: none;
    color: #e40000;
    font-size: .8rem;
    width: 100%;

}

select#dwn-pdf {
    margin-right: 1rem;
}

.download-btn-select-all {
    margin: 2rem auto;
}

.primary-font p.primary,
.victory-program-gray-box ul li {
    font-family: 'Roboto' !important;
}

.isi-text1 p {
    font-family: 'Open Sans';
}

u.primary.isi-blod {
    font-weight: 700;
    margin-top: 2rem;
    margin-bottom: .3rem;
    display: inline-block;
}

p.primary-padding-top {
    padding: 0 !important;
}

#p-top {
    padding-top: 1.5rem;
}

/* .victory-program #dosing-bottom-box .title {
   font-family: 'Montserrat';
} */
.victory-program #dosing-bottom-box .w-download-btn a {
    border-radius: 0;
}

.victory-program .title.main-text {
    max-width: 67%;
    margin: 0 auto;
}

.dwn-bttn {
    cursor: pointer;
    padding: 0.8rem 2rem;
    background: #0071CE;
    border: none;
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1.2rem;
    line-height: 1.2;
    text-decoration: none;

    text-align: center;

    color: #ffffff;
}

button.Send-to-patient.dwn-bttn {
    background: #6d6e71;
    opacity: 1 !important;
}

.download-section {
    border-bottom: 2px solid #0071CE;
    padding: 2.5rem 0 1.5rem;
    position: relative;
}

.download-section input[type=checkbox] {
    position: relative;
    border: 2px solid #0071CE;
    border-radius: 2px;
    background: none;
    cursor: pointer;
    line-height: 0;
    margin: 0 .6em 0 0;
    outline: 0;
    padding: 0 !important;
    vertical-align: text-top;
    height: 35px;
    width: 35px;
    -webkit-appearance: none;
    opacity: .5;
}

.download-section input[type=checkbox]:hover {
    opacity: 1;
}

.download-section input[type=checkbox]:checked {
    background-color: #0071CE;
    opacity: 1;
}

.download-section input[type=checkbox]:before {
    content: '';
    position: absolute;
    right: 50%;
    top: 50%;
    width: 8px;
    height: 20px;
    border: solid #FFF;
    border-width: 0 3px 3px 0;
    margin: -1px -1px 0 -1px;
    transform: rotate(45deg) translate(-50%, -50%);
    z-index: 2;
}

.download-check-box {
    display: inline-flex;
    justify-content: flex-end;
    width: 100%;
    position: absolute;
}

.download-check-box fieldset {
    font-size: 0;
}

.download-check-box label {
    font-size: 0;
}

.download-thumbnail {
    background: transparent;
    max-width: 200px;
    flex: 0 0 200px;
    width: 20%;
    margin-right: 2rem;
}

#widget-3 {
    margin-bottom: 3rem;
}

a.download-pdf-lang.dwn-bttn {
    margin-left: 1rem;
    display: flex;
    align-items: center;
    padding: 0 5rem;
}

select.dwn-pdf {
    max-width: 390px;
    width: 100%;
    border: 1px solid #0071CE;
    padding: 0.8rem 0.5rem;
    height: 45px;
    -webkit-appearance: none;
    background: url('/~/media/6BCAE7F175B144BBB5ECFC4A015E9EE1.ashx') no-repeat;
    background-position: 97% center;
}

select.toparrow {
    background: url('/~/media/CDD5B841A98E40A5B1B8E4307551E78A.ashx') no-repeat;
    background-position: 97% center;
}

.download-pdf-main {
    display: flex;
    align-items: center;
}

.download-description {
    max-width: 800px;
    width: 80%;
    padding: 0.5rem 2rem;
}

.download-dropdown {
    display: flex;
    width: 100%;
    margin-top: 2rem;
}

.download-mdl {
    display: flex;
    flex-wrap: wrap;
    max-width: 77%;
}

.quantum-header__left {
    width: 190px;
}

.quantum-header__logo {
    width: 100%;
    padding: 0px;
    max-height: inherit;
}

div#header {
    background: #F2F2F2;
    -webkit-box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    -moz-box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);

}

.download-dropdown fieldset {
    display: flex;
    width: 100%;

}

.download-dropdown legend {
    font-size: 0;
}

.download-dropdown label {
    font-size: 0;
    height: 0;
    display: block;
}

.quantum-drop-down-menu__link,
.quantum-drop-down-menu__menu-link {
    /*font-family: 'Roboto';*/
    font-family: 'Futura PT';
    font-weight: 400;
    font-style: normal;
    font-size: 1rem;
    line-height: 1.2;
    color: #6d6e71;
}

.quantum-drop-down-menu__link {
    font-weight: 500;
    font-size: 1.125rem;
}

div#main-cnt {
    padding: 0 15px;
}

p.blue-text {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.2rem;
    line-height: 1.5;
    color: #6D6E71;
    padding: 1rem 0;
}

.title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.875rem;
    line-height: 1.2;
    text-transform: uppercase;
    color: #0071CE;
}

html[lang="fr"] .title {
    font-size: 2rem;
}

.accordion .field-content p.tit-blue,
.tit-blue,
.gray-boxs p.tit-blue {
    color: #0071CE;
}

.inner-page-banner .download-section .download-title.title {
    padding-right: 3rem;
    text-transform: inherit;
    font-size: 1.5rem;
    color: #6D6E71;
    font-weight: 500;
}

.title span {
    font-weight: 400;
}

.title-flex {
    display: flex;
}

.moa-md-sec {
    margin: 1rem 0;
}

.inner-page-banner>div.row.component.column-splitter {
    align-items: center;
}

div#moa-md-right-img,
div#moa-md-sec div {
    padding: 0;
}

.moa-md-sec p {
    font-family: 'Open Sans';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.5;
    color: #0071CE;

}

span.line {
    padding: 0 0.5rem;
    color: #fff;
}

span.line::before {
    display: none;
}

/* .line::before {
   content: "";
   width: 20px;
   display: inline-block;
   color: #EB2244;
   background: #EB2244;
   border-radius: 20px;
   padding: 10px 0;
   margin: 0.3rem 1rem 0.3rem 0;
} */

.line::before {
    content: "";
    width: 1px;
    color: #EB2244;
    background: #EB2244;
    border-radius: 20px;
    padding: 0 7px;
    margin: 0.5rem 1rem 0.5rem 0;
    height: auto;
    position: relative;
    display: none;
}

.gray-bg {
    background: #FFA400;
    padding: 0.5rem 1rem;
    margin: 0rem 0;
}

.gray-bg p {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.5;
    color: #000;
    padding: 0.5rem 0;
}

.gray-bg p a {
    color: #0071CE;
    text-decoration: none;
}

sup {
    vertical-align: super;
    font-size: 60%;
}

.slide .component-content {
    display: flex;
    align-items: center;

}

.carousel-inner li.slide {
    padding: 2rem 1rem;
}

.component.carousel {
    background: #979797;
    position: relative;
}

.carousel .carousel-inner {
    background: rgba(255, 255, 255, 0.9);
}

.carousel-inner .nav {
    position: absolute;
    right: 2rem;
    bottom: 1rem;
}

#vectbix-victory p.tit-blue.margin-bottom1.p-fnt-15:lang(fr) {
    font-weight: bold;
}

.carousel-inner .nav .sxa-bullets {
    width: .9rem;
    height: .9rem;
    border-radius: 50%;

    border: 1px solid #6D6E71;
    margin: 0.2rem;
    cursor: pointer;

}

.carousel-inner .field-slidetext {
    padding: 1rem 2rem;
}

.slide1-logo {
    margin-top: 3rem;
    max-width: 300px;
}

.slide-title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 2.25rem;
    line-height: 1.2;
    color: #0071CE;
    padding: 1rem 0;
}

.slide-title a {
    color: #0071CE;
    text-decoration: underline;
    font-weight: 700 !important;
}

.slide-title span {
    font-weight: 600;
}

span.nosapce.n1 {
    font-weight: normal;
    letter-spacing: -4px;
}

.carousel-inner .nav .sxa-bullets.active {
    background: #6D6E71;
}

#footer-top>.component-content {
    padding: 1rem;
}

.carousel-inner .nav .nav-items {
    display: flex;
    align-items: center;
    justify-content: space-between;
}

div#moa-md-sec,
#cnt-custom,
.cnt-custom {
    margin: 2rem auto;
}

#footer-top {
    background: #F2F2F2;
    position: relative;
    margin-top: 0rem;
    padding: 0;

}

#home #footer-top {
    margin-top: 3rem;
}

.mar-4 {
    margin: 4rem 0;
}

#footer-top .component-content {
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
}

#footer-top .component-content ul {
    display: inline-flex;
}

footer#footer ul {
    display: inline-flex;
    border-bottom: 1px solid #fff;
    padding-bottom: 8px;
}

#footer-top .component-content ul li a {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.2rem;
    line-height: 1.1;
    color: #6D6E71;
    text-decoration: none;

}

#vectbix-victory.inner-page-banner .quantum-banner__inner {
    padding-bottom: 0;
}

#footer-top .component-content ul li .field-link::after,
footer#footer ul li .field-link::after {
    content: "|";
    padding: 0 0.5rem;
}

footer#footer ul li .field-link::after {
    color: #fff;
}

footer#footer li.item2.odd.last .field-link::after {
    display: none;
}

#footer-top .component-content ul li .field-link::after {
    line-height: 0;
    font-size: 19px;
}

#footer-top .component-content ul li:last-child .field-link::after {
    display: none;
}

.pad-15 {
    padding-left: 18px;
}

.cnt-custom.pad-15 {
    margin: 0;
}

.carousel-inner .slide .component.content.col-12 {
    padding: 0;
}

footer#footer ul li:last-child a::after,
#footer-top .component-content ul li:last-child a::after {
    display: none;
}

#footer-top .component-content ul li a:hover {
    text-decoration: underline;
}

.footer-logos {
    display: flex;
    align-items: baseline;
    justify-content: flex-end;
    width: 100%;
    margin-bottom: 1.2rem;
}

img.ml-32 {
    height: 80px;
}

footer#footer {
    background: #0063C3;
    padding-bottom: 1rem;
}

#footer-amgen-logo img {
    width: 164px;
    margin: 2rem 0;
}

footer#footer ul li a {
    font-family: 'Helvetica';
    font-style: normal;
    font-weight: 400;
    font-size: 0.875rem;
    line-height: 1.1;
    color: #FFFFFF;
    text-decoration: none;
    border-bottom: 1px solid #fff;
}

.quantum-banner {
    position: relative;
    margin-bottom: 0rem;
}

.home-banner-text,
#home .quantum-banner__title,
h1.eyebrow {

    margin: 7rem 0rem 0;
    font-family: 'Futura PT';
    text-transform: uppercase;
    font-style: normal;
    font-size: 2.5rem;
    line-height: 1;
    color: #0071CE;
    padding: 0 1rem;
    font-weight: 400;
}

#home h1.eyebrow span.bg-fnt {
    font-size: 6rem;
    line-height: 1.5;
    font-weight: 400;

}

.m-auto {
    margin: 0 auto;
    padding: 0;
}

p.no-padding,
.no-padding {
    padding: 0;
}

#orange-bottom-box #cnt-custom,
#orange-bottom-box .cnt-custom {
    margin: 0 auto;
}

div#top-header {
    padding: 0px;
    background: #0063C3;
}

#footer img.ml-32.Paab-logo {
    height: 46px;
    margin-right: 2rem;
}

#footer-copy-text {
    padding: 0;
    margin: 1rem 0;
}

.footer-content p {
    font-family: 'Helvetica';
    font-style: normal;
    font-weight: 400;
    font-size: 0.875rem;
    line-height: 1.4;
    color: #FFFFFF;
}

#footer .component.container.col-12 {
    padding: 0;
}

#footer>.component.container.col-12 {
    padding: 0 15px;
}

/* footer#footer div {
   padding: 0px;
} */
.quantum-banner__inner {
    max-width: 100%;
}

.banner .quantum-banner--multiple-background-images .quantum-banner__inner {
    max-width: 100%;
    padding: 0;
    display: block;
}

.callout {
    display: flex;
    justify-content: flex-end;
    margin-right: 1rem;
}

h1.quantum-banner__title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 300;
    font-size: 3rem;
    line-height: 1.3;
    color: #0071CE;
    text-align: left;
    margin-bottom: 0;

}

.component.rich-text.cnt-custom .inner-page-banner h1.quantum-banner__title {
    padding-top: .8%;
}

.inner-page-banner h1.quantum-banner__title {
    font-weight: 400;
}

.inner-page-banner h1.quantum-banner__title span {
    font-weight: 700;
    font-size: 2.25rem;
    display: block;
    color: #6D6E71;
    text-transform: inherit !important;
}

.gray-text {
    color: #6D6E71;
}

h1.quantum-banner__title span {
    text-transform: inherit !important;
}

#footer-bottom-top-logo>div>a {
    width: 200px;
    height: 49px;
}

#footer-bottom-top-logo>div>a img {
    width: 100%;
    height: auto;
}

body>div.row.component.column-splitter>div:nth-child(1),
body>div.row.component.column-splitter>div:nth-child(2),
div#moa-md-right-cnt {
    padding: 0;
}

div#moa-md-right-img>.component-content {
    display: flex;
    justify-content: flex-end;
}

ul.quantum-drop-down-menu__top-nav-list {
    display: flex !important;
    align-items: center;
    border: none;
    margin-right: 1rem;
    height: 100%;
    margin-left: 5px;
}

li.quantum-drop-down-menu__top-nav-list-item a {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 0.85rem;
    color: #FFFFFF;
    text-decoration: none;
}

.quantum-drop-down-menu__top-nav-link {
    padding: 12px 6px;
}

ul.quantum-drop-down-menu__top-nav-list li:first-child a::after {
    content: "\7c";
    padding: 0 0.5rem 0 0.5rem;
}

#top-header a.quantum-header__logo.d-block.d-sm-none.gtm-header {
    padding: 0.5rem 0;
}

.vidoe-mrg {
    margin: 2rem 0;
}

a.pipe::after,
.home-icon.pipe a::after {
    content: "\7c";
    padding: 0 0.5rem;
    text-decoration: none !important;
}

li.quantum-drop-down-menu__top-nav-list-item.french-lang a.pipe::after {
    display: none;
}

a.pipe::after:hover,
.home-icon.pipe a::after:hover {
    text-decoration: none !important;
}

a#lang-switch,
a.lang.quantum-drop-down-menu__top-nav-link {
    color: #fff;
    text-decoration: none;
    /* padding-left: .5rem; */
}

.quantum-drop-down-menu__top-nav-link li a {
    text-decoration: none;
}

.quantum-drop-down-menu__top-nav-link:hover {
    background: transparent;
}

a.lang.quantum-drop-down-menu__top-nav-link:hover {
    background: transparent;
}

#top-header>div>div>div>div.quantum-header__right>div.quantum-header__menu>nav>ul.quantum-drop-down-menu__list {
    display: none;
}

img {
    max-width: 100%;
    height: auto;
}

.flx {
    display: flex;
}

.f-note,
.accordion .field-content p.f-note-small {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 300;
    font-size: 1rem;
    line-height: 1.5;
    color: #6D6E71 !important;
}

.f-note {
    font-weight: 400;
}

.title span.big-text {
    font-family: 'Montserrat';
    font-style: normal;
    font-weight: 700;
    font-size: 6rem;
    line-height: 1;
    color: #EB2244;
}

#slider-home .field-slideimage {
    max-width: 400px;
    width: 100%;
}

#slider-home .slide-info {
    width: 67%;
    height: auto;
    min-height: auto !important;
}

p.blue-text strong {
    font-weight: 600;
}

.dor.line.title-flex {
    margin-bottom: 3rem;
}

.dor.line.title-flex::before {
    margin: 0.8rem 1rem 0.8rem 0;
}

.dor.line.title-flex p {
    padding: 0;
    line-height: 1.7;
}

.median-time {
    font-family: 'Montserrat';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1;
    text-align: center;
    color: #1F5680;
    padding: 1.3rem;
    max-width: 1140px;
    background: #ebf6f5;
    margin: 0px auto 2rem;
    border-radius: 30px;
}

.btn-group {
    display: flex;
    justify-content: space-evenly;
    max-width: 520px;
    margin: 0 auto;
}

.btn-group.btn-group-fr {
    max-width: 580px;
}

.bttn {
    background: #0071CE;
    text-align: center;
    color: #fff;
    display: inline-block;
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.1;
    padding: 0.6rem 2.4rem;
    border-radius: 0;
    cursor: pointer;
    border: none;
    margin: 0 0.5rem;
    text-decoration: none;
}

.visit-pubMed.bttn a {
    color: #fff;
    text-decoration: none;
}

footer#footer .field-link {}

.learn-about-codebreak {
    margin-top: 2rem;
    text-align: center;
    margin-bottom: 1rem;
}

.visit-pubMed {
    margin-bottom: 3rem;
}

.ref-sec p {
    color: #143757;
    line-height: 2;
}

.quantum-modal__dialog.quantum-modal__dialog--fit-content {
    max-width: 1200px;
}

.study-popup-img {
    margin: 1rem 0 2rem;
}

.new-tit {
    text-transform: inherit;
    font-size: 1.75rem;
    color: #6D6E71;
    font-weight: 700;
    margin-top: 1rem;
}

.popup-title {}

.title-icon {
    display: flex;
    margin-right: 2rem;
    width: 100px;
    height: 100px;
}

.text-algin-left {
    text-align: left !important;
}

.table-max-w {
    max-width: 900px;
    margin-left: auto;
    margin-right: auto;
}

.popup-title-text {
    width: 90%;
}

.patient-td {
    font-family: 'Montserrat';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.5;
    color: #000000;
}

.patient-td.first-clounm {
    font-weight: 700;
    width: 40%;
}

.patient-dem-table {
    margin: 2rem;
    position: relative;
}

.patient-tr {
    display: flex;
}

.patient-td {
    width: 60%;
    padding: 0.5rem 2rem;
}

.quantum-modal__dialog,
.quantum-modal .quantum-modal__dialog {
    height: auto;
    margin: auto;
    bottom: auto;
    top: 0px;
    position: absolute;
    left: 0;
    right: 0;
}

#obu-corporate-link-canada .quantum-modal__dialog,
#obu-corporate-link-canada .quantum-modal .quantum-modal__dialog,
#obu-external-link .quantum-modal__dialog,
#obu-external-link .quantum-modal .quantum-modal__dialog,
#AmgNav .quantum-modal__dialog,
#AmgNav .quantum-modal .quantum-modal__dialog,
#obu-corporate-link-canada .quantum-modal .quantum-modal__dialog,
#obu-corporate-link-canada .quantum-modal .quantum-modal__dialog,
#obu-external-link-canada .quantum-modal__dialog,
#obu-external-link-canada .quantum-modal .quantum-modal__dialog {
    position: relative;
}

#obu-corporate-link-canada,
#obu-external-link,
#AmgNav,
#obu-corporate-link-canada,
#obu-external-link-canada {
    display: flex;
}

#obu-external-link .quantum-modal__dialog {
    top: 70px;
}

.quantum-modal.quantum-modal--visible {
    overflow-y: scroll;
}

#kyprolis-isi-popup.quantum-modal.quantum-modal--visible {
    overflow-y: scroll;
}

div#isi-popup .quantum-modal__dialog.quantum-modal__dialog--fit-content.quantum-modal__dialog--fit-full {
    padding: 3rem 2rem 2rem;
}

p.primary,
footer#footer .isi-ul ul li,
.isi-main-page ul li,
.pop-p {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.3rem;
    line-height: 1.5;
    color: #6D6E71;
    padding: 0.5rem 0;
}

footer#footer .isi-ul ul li {
    padding: 0.2rem 0;
}

footer#footer .isi-text {
    padding: 0.3rem .8rem;
    border: 2px solid #0071CE;
    margin: 2rem 0 0;
}

footer#footer .isi-ul ul,
.isi-main-page ul {
    display: block;
    list-style: disc;
    margin: 0 1.8rem;
}

p.primary a {
    color: #0071CE;
    text-decoration: underline;
    word-wrap: break-word;
}

.isi-continue {
    margin-top: 1rem;
}

.vectibix-home .cnt-custom {
    padding: 0;
}

.vectibix-home .px-15 {
    padding: 0 15px;
}

.blue-box {
    background: url(/-/media/BD123A16C63F4F3CBA1EBFC14A17464E.ashx?h=16&thn=1&w=16) no-repeat center / cover;
    font-family: 'Futura PT';
    color: #fff;
    padding: 80px 120px 80px 200px;
    font-size: 34px;
    position: relative;
    margin-bottom: 50px;
    line-height: 1.2;
}

.blue-box a {
    color: #fff;
}

.blue-box::before {
    content: '';
    position: absolute;
    background: url(/-/media/491EF9309C014980A253B1B003F2F042.ashx?h=16&thn=1&w=16) no-repeat center / contain;
    height: 120px;
    width: 120px;
    left: 50px;
    top: 50%;
    transform: translateY(-50%);
}

@media only screen and (max-width: 600px) {
    .isi-continue {
        padding-bottom: 3rem;
    }
}

.isi-continue .bttn {
    font-weight: 700 !important;
    margin: 0;
}

.patient-dem-table::before,
.safety-tabf-table::before {
    content: "";
    width: 20px;
    height: 100%;
    background: #73BCA8;
    position: absolute;
    border-radius: 20px 0 0 20px;
    left: -20px;
}

.patient-tr:nth-of-type(odd) {
    background: rgba(0, 0, 0, 0.02);
}

.tabs .component-content .tabs-inner .tabs-container .tab {
    padding: 2rem 0 0;
}

.tabs .component-content .tabs-inner .tabs-heading li {
    width: 50%;
    background: #6d6e71;
    border-radius: 1rem 1rem 0 0;
    border: none;
}

.tabs .component-content .tabs-inner .tabs-heading li:last-child,
.tabs .component-content .tabs-inner .tabs-heading li:first-child {
    border-radius: 1rem 1rem 0 0;
    border: none;
}

.tabs .component-content .tabs-inner .tabs-heading li:last-child {
    margin-left: .3rem;
}

.tabs .component-content .tabs-inner .tabs-container {
    border: none;
    background: #fff;
}

.tabs .component-content .tabs-inner .tabs-heading li:first-child {
    margin-right: .3rem;
}

.tabs .component-content .tabs-inner .tabs-heading li.active,
.tabs .component-content .tabs-inner .tabs-heading li.active:hover {
    background: #0071CE;
    color: #fff;
    border: none;
    border-radius: 1rem 1rem 0 0;
    border-radius: 1rem 1rem 0 0;

}

.tabs .component-content .tabs-inner .tabs-heading li:hover {
    background: #0071CE;
    border: none;
}

.tabs .component-content .tabs-inner .tabs-heading li>div {
    color: #fff;
    white-space: initial;
}

.tabs .component-content .tabs-inner .tabs-heading li>div .field-heading {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1.5rem;
    line-height: 1;
    text-align: center;
    color: #FFFFFF;
}

.tabs .component-content .tabs-inner .tabs-heading {
    border-bottom: 10px solid #0071CE;
}

ul.tabs-heading::after {
    content: "";
    width: 100%;
    position: absolute;
    left: -100%;
    background: #0071CE;
    height: 10px;
    bottom: -10px;
}

ul.tabs-heading::before {
    content: "";
    width: 100%;
    position: absolute;
    right: -100%;
    background: #0071CE;
    height: 10px;
    bottom: -10px;
}

/* .tabs .component-content .tabs-inner .tabs-heading{
   padding: 0 4rem;
} */
.safety-tabf-table {
    margin: 0 0 2rem 1.25rem;
    position: relative;
}

.safety-tabf-table-main {
    margin: 2rem 0;
    position: relative;
}

.tabf-table-td,
.tabf-top-table-td {
    width: 33.33%;
    padding: 1rem;
    font-family: 'Open Sans';
    font-style: normal;
    font-weight: 400;
    font-size: 1.25rem;
    line-height: 1.3;
    color: #0071CE;

}

.tabf-table-tr.tr-no-border {
    border: none;
}

.tabf-table-tr {
    display: flex;
    border-bottom: 3px solid rgba(0, 0, 0, 0.04);
}

.tabf-table-td.tabf-table-td-head {
    font-weight: bold;
    background: #FAFAFA;
    width: 100%;
    border: none;
}

.tabf-top-table-td {
    text-align: center;
    font-weight: 700;
}

.tabf-top-table-td.tabf-top-table-head {
    width: 66.66%;
    text-align: center;
}

.tabf-top-table-td.dblue {
    background: #0B3657;
    color: #fff;
}

.tabf-top-table-td.tabf-top-table-head {
    border: 2px solid #73BCA8;
}

.tabf-top-table-td.lblue {
    background: #0071CE;
    color: #fff;
}

.tabf-table-td:nth-child(2),
.tabf-table-td:nth-child(3) {
    text-align: center;
}

.tabf-top-table-tr {
    display: flex;
    justify-content: flex-end;
}

.safety-tab2 ul {
    list-style: disc;
    margin-left: 2rem;
}

.safety-tab2 ul li {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.5;
    color: #0071CE;
    padding: .4rem 0;
}

.tab3-table1 ul {
    margin: 1.3rem;
    list-style: disc;
}

ul.tab3-table-ul-child {
    margin: 0 2rem;
}

.tab3-table1 ul li {
    font-family: 'Montserrat';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.6;
    color: #0071CE;
}

.safety-tab2 {
    margin-bottom: 2rem;
}

.tab3-table {
    padding: 0 1rem;
}

.safety-tab3 {
    display: flex;
}

.tab3-table1 {
    background: rgba(0, 0, 0, 0.04);
    margin-right: 0.8rem;
    width: 50%;
}

.tab3-table1-title {
    background: #0071CE;
}

.tab3-table1-title p.blue-text {
    color: #fff;
    font-size: 1rem;
    padding-left: 1.2rem;
    font-weight: 600;
}

.tab3-table.table-3 p.blue-text {
    font-size: 1.125rem;
    font-family: 'Montserrat';
}

div#slider-home {
    padding: 0;
    background: #F5F5F5;
    margin: 3rem 0;
}

.tab3-table-titel {
    margin-top: 2rem;
}

.dosing-c-border {
    display: flex;
    justify-content: flex-end;
    margin: 0 auto 3rem;
    position: relative;
}

h4.dosing-kras-title.title {
    max-width: 720px;
}

.dosing-kras {
    padding: 1.5rem 2rem;
    border-top: 10px solid #EB2244;
    border-left: 10px solid #EB2244;
    border-bottom: 10px solid #EB2244;
    border-radius: 30px 0 0 30px;
}

.dosing-kras:after {
    content: "";
    height: 10px;
    position: absolute;
    width: 100%;
    background: #EB2244;
    bottom: 0;
}

.dosing-kras::before {
    content: "";
    height: 10px;
    position: absolute;
    width: 100%;
    background: #EB2244;
    top: 0;
}

.recommended ul {
    margin: 0;
    list-style: disc;
    padding: 0 2rem;
}

.recommended ul li {
    font-family: 'Open Sans';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.4;
    color: #0071CE;
    padding: 0 0 0.5rem 0;
}

.how-to-take-lumakras {
    display: flex;
    justify-content: space-between;
    margin: 3rem 0;
}

.how-to-take-lumakras-cnt {
    width: 26%;
}

.how-to-take-lumakras-icon img {
    margin: 0 auto;
}

.how-to-take-lumakras-icon {
    display: flex;
    align-items: center;
    position: relative;
    padding-bottom: 2rem;
}

.how-to-take-lumakras-icon::after {
    content: "";
    height: 10px;
    width: 100%;
    background: #EB2244;
    position: absolute;
    left: 0;
    bottom: 0;
    border-radius: 10px;
}

.how-to-take-lumakras-des a {
    text-decoration: underline;
    color: #0071CE;
}

div#dosing-confirm-presence_ {
    position: relative;
    overflow: hidden;
    padding: 0;
}

div#dosing-page,
#widget-1 {
    padding: 0;
}

.line-height,
.line-height ul li {
    line-height: 2 !important;
}

.isi-main-page p,
ul#isi-ul li {
    font-family: 'Open Sans' !important;
}

.img-part2 img {
    margin-top: 3rem;
}

.how-to-take-lumakras-des ul,
.victory-program-gray-box ul {
    list-style: disc;
    margin-left: 2rem;
}

p.primary.blue-title2-padding.padding-top {
    padding-top: 2rem;
}

.title.padding-top-b,
.padding-top-b {
    padding: 1.2rem 0;
}

.how-to-take-lumakras-des ul li,
.victory-program-gray-box ul li {
    font-family: 'Open Sans';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.5;
    color: #0071CE;
}

.title a {
    color: #fff;
}

.title.victory-program-title a {
    color: inherit;
    text-decoration: none;
}

.victory-program-gray-box ul li {
    font-size: 1.125rem;
}

.victory-program-gray-box p.blue-text {
    font-weight: 600;
}

.victory-program.line.title-flex {
    margin: 1rem 0;
}

.dose-modification-recommended,
.dose-modification-f-note {
    margin-top: 5rem;
}

.dose-modification-f-note p.f-note {
    padding: 1rem 0;
}

.patients-difficulty-icon {
    width: 100px;
    margin: 1.5rem 2rem 1.5rem 0;
}

.patients-difficulty-list {
    display: flex;
}

.alternative-dosing-method {
    width: 75%;
}

.alternative-dosing-method.line::before {
    min-height: 90px;
}

.alternative-dosing-method.line.title-flex {
    align-items: center;
}

.patients-difficulty {
    margin: 2rem 0;
}

#dosing-bottom-box {
    padding: 1rem 0;
    background: #0071CE url('/~/media/F72621F1B1844F61AF694003702A8DAA.ashx');
    margin-top: 0rem;
    margin-bottom: 0rem;
    background-repeat: no-repeat;
    background-position: 93% center;
}

/*.cus-table{width: 96%;
   margin-left: auto;
   margin-right: auto;}
.cus-foot{padding-bottom: 25px;
   border-bottom: solid 1px #6D6E71;
   }*/
#dosing-bottom-box .title {
    color: #fff;
    padding: 2rem 0;
    text-transform: inherit;
}

a.w-bttn.bttn {
    background: #fff;
    color: #0071CE;
    display: inline-block;
    margin: 0;
    text-decoration: none;
    font-weight: 500;
}

a.p-bttn.bttn {
    background: #0071CE;
    color: #ffffff;
    display: inline-block;
    margin: 0 0.5rem 1.5rem;
    text-decoration: none;
}

.drug-interactions-tr {
    display: flex;
    border-bottom: 3px solid rgba(0, 0, 0, 0.2);
}

.drug-interactions-td {
    width: 100%;
    flex: 0 auto;
}

.drug-interactions-td.gray-bg.drk {
    width: 44%;
}

.drug-interactions-top-title {
    margin: 0px 8rem 3rem;
}

p.drug-interactions-title {
    font-weight: 700;
}

.drug-interactions-td.gray-bg.drk {
    background: #D9D9D9;
}

.gray-bg.round-corner {
    padding: 2rem 4rem;
    border-radius: 40px;
}

.title.victory-program-title span {
    font-weight: 400;
}

.isi-main-page .isi-text {
    border: 2px solid #0071CE;
    padding: .8rem 1rem;
    margin: 1rem 0 2rem;
}

ul#isi-ul {
    margin: 0 1.8rem 0rem;

}

ul#isi-ul li,
ul#isi-ul-box li {
    padding: 0;
}

p.primary.isi-blod {
    font-weight: 700;
}

ul#isi-ul-box {
    margin: 0 2.5rem;
}

.isi-main-page,
.references-page {
    margin-bottom: 5rem;
}

.references-page ol {
    list-style: auto;
    margin-left: 2rem;
}

.references-page ol li {
    font-family: 'Open Sans';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.5;
    color: #0071CE;
    padding: 1rem 0;

}

.pai-graph-table p.f-note {
    margin: 2rem 0 0;

}

.nowrap {
    white-space: nowrap;
}

.quantum-banner__image-area,
.sp-only {
    display: none;
}

/* a.quantum-drop-down-menu__link.active {
   background: red;
} */

#patient-resources .download-section {
    padding: 1.5rem 0;
}

.download-des-text {
    width: 100%;
}

#footer #cnt-custom,
#footer .cnt-custom {
    padding: 0;
    margin: 0 auto;
}

.moa-text ul {
    list-style: disc;
    margin-left: 1.5rem;
}

.dgrays {
    color: #303234 !important;
}

.moa-text ul li,
.moa-text p {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.3rem;
    line-height: 1.2;
    color: #303234;
    padding: 0.2rem 0;
}

#moa-vectibix {
    background: #F1F1F1;
}

#moa-vectibix .component.rich-text.col-12.col-sm-12.cnt-custom {
    background: #fff;
    margin: 0;
    padding: 50px 50px;
    max-width: 100%;
}

.l0 {
    line-height: 0;
}

.moa-sec1 {
    margin-bottom: 3rem;
    align-items: center;
}

.moa-text ul ul {
    margin-left: 2.2rem;
    margin-top: 0.5rem;
}

/*admin-page styles*/

.admin-page p.primary {
    font-family: 'Futura PT';
    font-size: 1rem;
    line-height: 1.1;
}

.administration ul#isi-ul li {
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.1;
    color: #0071CE;
    padding: 0.5rem 0;
    font-family: 'Futura PT';
    list-style: disc;
}

.administration ul.order-list li {
    margin-left: 39px;
}

.administration span.bold-text {
    font-weight: 700;
}

.administration-program-gray-box p.blue-text {
    font-weight: 700;
    color: #000;
}

.administration-program-gray-box ul {
    list-style: disc;
    margin-left: 1.5rem;
}

.administration-program-gray-box ul li {
    font-size: 1.125rem;
    line-height: 1.5;
    font-family: 'Futura PT';
    font-weight: 400;
    color: #000;
    padding: 0.3rem 0;
}

div#orange-bottom-box {

    margin-top: 4rem;
    background-color: #FFA400;
}

.bg-clr.administration-page {
    background-color: unset;
}



.bg-clr .title.victory-program-title {
    text-align: center;
    justify-content: center;
    margin: 0 auto;
    max-width: 64%;
    padding-right: 0;
    color: #000;
    font-family: 'Futura PT';
}

.bg-clr {
    background-color: #FFA400;
    padding: 21px;
    /* margin-bottom: 20px; */
}

.title.main-text {
    text-align: center;
    line-height: 1.5;
}

a.download-pdf-lang.dwn-bttn.pub-med {
    padding: 0.8rem 5rem;
    margin-left: 0;
}

p.small-txt {
    font-size: 1rem;
    padding: 0;

}

.orange-line {
    border-bottom: 3px solid #FFA400;
    margin: 2rem 0;
}

.field-heading:after {
    color: transparent;
    background-position: center;
    background-size: contain;
    background-repeat: no-repeat;
    font-size: 2.2rem;
    content: '';
    position: absolute;
    right: 6px;
    top: 40%;
    bottom: 0;
    width: 24px;
    height: 24px;
    background-image: url('/~/media/52CE686FAA5B46888CD1BF3684127D10.ashx');
}

.field-heading {
    border-top: 1px solid #0071CE;
    line-height: 1.2;
    padding: 2rem 0 0;
    position: relative;
    cursor: pointer;
}

.tabs-heading .field-heading {
    padding-top: .5rem;
    margin-bottom: 1rem;
}

ul.items li:last-child.item .field-heading {}

ul.items li.item .field-heading {
    border-bottom: 1px solid #6D6E71;
    padding-bottom: 1.5rem;
}

ul.items li.item.active .field-heading {
    border-bottom: 0;
}

li.item {
    list-style: none;
}

.items .item.active:last-child .field-heading {
    border-bottom: none;
}

li.item.active .field-heading:after {
    background-image: url('/~/media/752FD34D286948279F1BB83C6D3838F5.ashx');
}

.component.accordion.cnt-custom.initialized,
.component.accordion.initialized {
    padding: 0 15px;
    margin-bottom: 4rem;
}

.component.accordion.cnt-custom.initialized .component-content,
.component.accordion.initialized .component-content {
    box-shadow: 10px 0px 21px #ccc;
}

.label .component.content.col-12,
.label .component.content.col-12 .component-content,
.toggle-content .component.content.col-12 .component-content {
    box-shadow: none;
}

.pai-graph {
    margin-top: 3rem;
}

.pai-graph-title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 700;
    font-size: 1.5rem;
    line-height: 1.1;
    text-align: center;
    color: #275776;
    margin-bottom: 1rem;
}

.pai-graph-table {
    margin-top: 5rem;
}

.pai-graph-content {
    display: flex;
    justify-content: space-between;
}

.Send-to-patient.dwn-bttn.model-pop-up-open {
    display: inline-block;
    margin: 4rem 0 0;
}

.dwn-bttn.model-pop-up-open {
    opacity: 1 !important;
}

.pai-graph-img1 {
    margin-right: 3rem;
}

.sub-title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.3;
    color: #0071CE;
    margin-top: .6rem;
}

.popup-des .f-note {
    padding: 1rem 0;
}

#tower-trial-tab .field-heading {
    border: none;
}

#tower-trial-tab .field-heading:after {
    content: none;
}

.blue-title2 {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.2;
    color: #0071CE;
}

.blue-title2-padding {
    padding: 1rem 0 2rem;
}

.bttn {
    border: 0px !important;
}

.title3 {
    font-size: 2.625rem;
    font-weight: 300;
    font-family: 'Futura PT';
    line-height: 1.3;
}

.blue-title3 {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 2.25rem;
    line-height: 1.2;
    color: #0071CE;
}

.title.graph-title {
    text-align: center;
    margin: 4rem 0 0;
}

.bottom-line {
    border-bottom: 5px solid #FFA400;
    padding-bottom: 0.7rem;
}

.tab-cnt {
    margin: 2rem 0 0;
}

.tab-cnt .title.title2.margin-bottom2.margin-top3,
.tab-cnt .title.margin-bottom3.margin-top3 {
    text-transform: inherit;
    color: #6D6E71;
}

.graph-img {
    margin-bottom: 3rem;
}

p.title.blue-title2-padding.align-center {
    margin: 0 auto;
    max-width: 1040px;
}

.study-design-btn {
    display: table;
    margin: 0 auto;
    /* max-width: 220px; */
}

.study-design-yellow-bg {
    background: #FFA400;
    padding: 1rem;
    margin-bottom: 2rem;
    -webkit-box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
    -moz-box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
    box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
}

.tab-full-w-color-box::after {
    content: "";
    background: #275776;
    position: absolute;
    right: -100%;
    width: 100%;
    top: 0;
    bottom: 0;
}

.tab-full-w-color-box::before {
    content: "";
    background: #275776;
    position: absolute;
    left: -100%;
    width: 100%;
    top: 0;
    bottom: 0;
}

.study-design-f-note {
    margin: 4rem 0 0;
}

.blue-title3-padding {
    max-width: 901px;
    margin: 0 auto;
}

.margin-bottom {
    margin-bottom: 2rem;
}

.component.container.tab-content-1,
.component.container.tab-content-2 {
    max-width: 100%;
    padding: 0;
}

.graph-content {
    display: flex;
    align-items: center;
}

.align-center {
    text-align: center;
}

.accordion .field-heading {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1.2rem;
    color: #6D6E71;
    border: 0;
}

.accordion .field-content {
    margin-bottom: 1rem;
}

.accordion-ul ul {
    list-style: disc;
    margin: 0 1rem 0 1.2rem;
    padding: 0px;

}

.icon-text ol {
    margin-left: 2.3rem;
    list-style: decimal;
}

.icon-text ol li {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 300;
    font-size: 1.125rem;
    line-height: 1.3;
    color: #212426;
    padding: .5rem 0;
}

.accordion-ul ul li,
.accordion .field-content p {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1;
    color: #6D6E71;

}

.accordion .field-content .tab-table.blk table p {
    color: #000;
}

.acc-img {
    margin: 2rem 0;
}

strong {
    font-weight: 700;
}

.icons {
    display: flex;
    align-items: center;
    margin-bottom: 2rem;
}

.icon {
    flex: 0 0 100px;
}

.icon-text {
    flex: 0 0 88%;
}

.icon.icon-tyle2 {
    flex: 0 0 200px;
}

.icon-text.icon-text2 {
    flex: 0 0 80%;
}

:lang(en) .english-lang .lang-select span,
:lang(fr) .french-lang .lang-select span {
    text-decoration: underline !important;
}

.study-design-p,
.accordion .field-content .study-design-yellow-bg p {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.2;
    color: #000000;

}

.inner-page-banner .quantum-banner__inner {
    background: #fff;
}

.acc-td-des ul {
    list-style: disc;
    margin-left: 1.5rem;
}

.td-head,
.acc-td-des,
.acc-td-des ul li {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1.5rem;
    line-height: 1.2;
    color: #ffffff;
}

.acc-img .patient-group-td {
    border-right: 1px solid #275776;
    border-left: 1px solid #275776;
}

.acc-img .patient-group-tr {
    border-bottom: 2px solid #275776;
}

.acc-img .patient-group-table {
    border-left: 1px solid #275776;
    border-right: 1px solid #275776;
}

.acc-td-des,
.acc-td-des ul li {
    color: #275776;
}

.acc-td-des ul li {
    padding: 0 0 0.7rem 0;
}

.acc-td-col4 {
    flex: 0 0 90.6%;
}

.acc-td-head {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.5rem;
    line-height: 1.2;
    color: #ffffff;
}

.td-col1 {
    flex: 0 0 300px
}

.td-col1 {
    flex: 0 0 346px;
}

.patient-group-tr {
    border-bottom: 2px solid #ffffff;
}

.td-light-gray {
    background: #CCD1D6;
}

.td-light-gray2 {
    background: #E7E9EC;
}

.td-col2 {
    flex: 0 0 72%;
}

.patient-group-td {
    padding: 0.6rem 1rem;
    border-right: 2px solid #fff;
}

.td-des {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.3;
    color: #000;
}

.tr-blue {
    background: #275776;
}

.patient-group-tr {
    display: flex;
}

.acc-img .patient-group-tr,
.yellow-tr,
.pai-graph-tr {
    display: table-row;
}

.pai-graph-td,
.pai-graph-table-title {
    padding: .5rem;
    border: 1px solid #fff;
}

.acc-td-col1,
.acc-td-col2,
.acc-td-col3,
.yellow-td,
.pai-graph-td {
    display: table-cell;
}

.patient-group-tr.merge-rows {
    display: table;
    width: 100%;
    border-top: 2px solid #275776;
}

.yellow-tr-merge-cell,
.pai-graph-table2 {
    display: table;
    width: 100%;
}

.yellow-table-head {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 700;
    font-size: 1.125rem;
    line-height: 1.2;
    padding: 1rem;
    color: #fff;
    text-align: center;
}

.yellow-table {
    /* display: table; */
    width: 100%;
}

.yellow-col1 {
    width: 48%;
}

.yellow-td-bg {
    background: #FFA400;
}

.yellow-col2 {
    width: 15%;
}

.acc-td-col1 {
    width: 16%;
}

.graph-group-img {
    display: flex;
    justify-content: space-between;
}

footer#footer .row.component.column-splitter {
    align-items: flex-end;
}

.graph-img.graph-img-m0 {
    margin-bottom: 1rem;
}

div#dosing-bottom-box a {
    text-decoration: none;
    border-bottom: 3px solid #fff;
}

textarea,
input[type="text"],
input[type="button"],
input[type="submit"],
button {
    -webkit-appearance: none;
    border-radius: 0;
}

.patient-group-table.preparation-table {
    display: table;
    width: 100%;
    border-bottom: 1px solid #275776;
}

.patient-group-table.preparation-table .patient-group-td,
.patient-group-table.preparation-table .acc-td-head {
    border: 1px solid #275776;
    font-size: 1.125rem;
}

li.quantum-drop-down-menu__top-nav-list-item.home-icon a::before {
    content: "\f015";
    display: inline-block;
    font: normal normal normal 16px/1 FontAwesome;
    font-size: inherit;
    text-rendering: auto;
    -webkit-font-smoothing: antialiased;
    color: #fff;
    position: absolute;
    top: 9px;
    font-family: "FontAwesome";
    font-size: 1.2rem;
    left: -8px;
}

li.quantum-drop-down-menu__top-nav-list-item.home-icon span {
    visibility: hidden;
    display: none;
}

li.quantum-drop-down-menu__top-nav-list-item.home-icon {
    position: relative;
}

html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item.home-icon a:before {
    width: 25px;
    top: 10px;
}

html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item.home-icon a::after {
    content: "\7c";
    padding: 0 0.5rem 0 0.5rem;
}

div#obu-external-link {
    display: none;
    visibility: visible;
    opacity: 1;
    z-index: 999;
}

#obu-external-link button.quantum-button.quantum-button--tertiary.quantum-modal__close.quantum-button--icon-only,
#kyprolis-isi-popup button.quantum-button.quantum-button--tertiary.quantum-modal__close.quantum-button--icon-only {
    display: none;
}

button.blue-btn {
    border: none;
    padding: 0.5rem 1.5rem;
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.1;
    background: #0071CE;
    text-align: center;
    color: #fff;
    margin-top: 1.5rem;
    margin-right: 1rem;
    cursor: pointer;
}

.popup h2,
.content {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.125rem;
    line-height: 1.5;
    color: #6d6e71;
}

.padding-t0-btm1 {
    padding: 0 0 1rem;
}

.padding-t1-btm0 {
    padding: 1rem 0 0;
}

.title.tab-title {
    font-family: 'Futura PT';
    font-weight: 400;
    font-size: 2.5rem;
}

.tabs-container .title.tab-title {
    font-weight: 400;
    font-size: 3.125rem;
}

.title2 {
    font-size: 2rem;
}

.margin-top1 {
    margin-top: 1rem;
}

.margin-bottom1 {
    margin-bottom: 1rem;
}

.margin-top2 {
    margin-top: 2rem;
}

.margin-bottom2 {
    margin-bottom: 2rem;
}

.margin-top3 {
    margin-top: 3rem;
}

.margin-bottom3 {
    margin-bottom: 3rem;
}

.margin-top4 {
    margin-top: 4rem;
}

.margin-bottom4 {
    margin-bottom: 4rem;
}


.tab-table table {
    border: 1px solid #ffffff;
    border-collapse: collapse;
    margin: 0 auto;
    padding: 0px;
    table-layout: fixed;
    min-width: 100%;
    font-family: 'Futura PT';
    font-style: normal;
    font-size: 1.25rem;
    line-height: 1;
}

.acc-table-head {
    border: 1px solid #ffffff;
    background: #0071CE;
    color: #fff;
}

.tab-table table th {
    padding: 1rem;
    border-right: 2px solid;
    background: url('/~/media/8732D431F191460EA85E4413E1DBC0B1.ashx') no-repeat;
    color: #FFFFFF;
    text-align: center;
    font-weight: 400;
    font-family: 'Futura PT';
    font-style: normal;
    font-size: 1.5rem;
    line-height: 1;
    background-size: cover;
    vertical-align: middle;
}

.tab-table table th:first-child {
    border-left: solid 1px #80d2ea;
}

.tab-table table th:last-child {
    border-right: 1px solid #0491bc;
}

.base-txt {
    border-left: 10px solid #0071CE;
    font-family: 'Futura PT';
    padding: 1rem;
    margin: 2rem 0;
    text-align: left;
    font-size: 1.45rem;
    line-height: 1;
    color: #6D6E71;
    font-weight: 700;
    border-right: solid 10px #0071CE;
}


.tab-table table td {
    text-align: center;
    padding: 1rem;
    border: 1px solid #6D6E71;
    font-weight: 400;
    font-family: 'Futura PT';
    font-style: normal;
    font-size: 1.125rem;
    line-height: 1.2;
}

.chart-dark-color {
    background: #F1F1F1;
}

.chart-light-color {
    background: #fff;
}

.chart-light-color1 {
    background: rgba(251, 179, 23, 15%);
}

.vert-mid {
    vertical-align: middle;
}

.bg-none-tab {
    background: none !important;
    border: 0 !important;
}

.tab-table table tr {

    color: #000000;
    text-align: center;
}

.tab-table .accent-color {
    background: rgba(251, 179, 23, 15%);
}

.tab-table .accent-color-dark {
    background: #EDD1E1;
}

.hide {
    display: none;
}

ul.list-ul {
    list-style: disc;
    margin-left: 2.3rem;
}

ul.list-ul li {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1.4rem;
    line-height: 1.2;
    color: #0071CE;
    padding: .3rem 0;
}

.toggle-content ul.list-ul li {
    font-size: 1.3rem;
}

.padding20 {
    padding: 20px !important;
}

.txt-upp {
    text-transform: uppercase;
}

ul.list-ul.box-align-center {
    display: table;
    margin: 0 auto;
}

.download-a-copy-section-title,
.title3 {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 300;
    font-size: 2.625rem;
    line-height: 1.3;
    color: #6D6E71;
}

.p-new {
    font-style: normal;
    font-family: 'Futura PT';
    font-weight: 400;
    font-size: 1.3rem;
    color: #6D6E71;
    line-height: 1.2;
}

.download-a-copy-section-title a {
    color: #6D6E71;
    font-weight: 700;
}

.bg-yellow {
    background: #6d6e71;
}

.download-a-copy-section-title .download-a-copy-section-group .bttn-align-mdl {
    color: #ffffff;
    height: 55px;
    align-items: center;
    display: flex;
    font-weight: 500;
}

.img-center-align {
    display: block;
    margin: 0 auto;
}

.col-w70 {
    max-width: 940px;
    margin: 0 auto;
    text-align: center;
    width: 90%;
}

.download-a-copy-section-title {
    text-align: center;
    max-width: 1150px;
    margin: 0 auto;
    width: 80%;
}

#download-a-copy-section,
#download-a-copy-section-accent-90,
#download-a-copy-section-itreactive-90 {
    position: relative;
}

#download-a-copy-section-accent-90::before {
    content: "";
    width: 68px;
    position: absolute;
    top: 0;
    bottom: 0;
    height: 100%;
    background: #EDD1E1;
}

.itreactive-90-color {
    background: #DDEAF3;
}

#download-a-copy-section-itreactive-90::before {
    content: "";
    width: 68px;
    position: absolute;
    top: 0;
    bottom: 0;
    height: 100%;
    background: #DDEAF3;
}

.download-a-copy-section-group {
    display: flex;
    justify-content: center;
}

.accent-70-bgcolor {
    background: #FAC196;
    padding: 2rem 0;
    position: relative;
}

.accent-90-bgcolor {
    background: #EDD1E1;
    padding: 2rem 0;
    position: relative;
}

ul.list-ul.gray-li li {
    color: #6D6E71;
    font-family: 'Futura PT';
    list-style: none;
    position: relative;
    padding-left: 22px;
    font-weight: 400;
}

ul.list-ul.gray-li li:before {
    content: '●';
    font-size: 1rem;
    padding-right: 10px;
    position: absolute;
    left: 0;
    top: 12px;
    line-height: 0;
}

ul.list-ul.gray-li.top-20 li:before {
    top: 20px;
}

ul.list-ul.gray-li.top-201 li:before {
    top: 17px;
}

.title-w70 {
    max-width: 1000px;
    text-align: center;
    margin: 50px auto;
}

.mar-txt {
    margin-bottom: 5px;
}

.title-w70 p {
    font-size: 1.5rem;
    color: #303234;
}

ul.list-ul.box-align-center li {
    font-size: 2.188rem;
    font-weight: 300;
    margin-left: 3.3rem;
    font-family: 'Futura PT';
}

.accent-90-bgcolor::after {
    content: "";
    width: 100%;
    top: 0;
    bottom: 0;
    background: #EDD1E1;
    position: absolute;
    right: -98%;
}

.accent-90-bgcolor::before {
    content: "";
    width: 100%;
    top: 0;
    bottom: 0;
    background: #EDD1E1;
    position: absolute;
    left: -98%;
}

.accent-70-bgcolor::after {
    content: "";
    width: 100%;
    top: 0;
    bottom: 0;
    background: #FAC196;
    position: absolute;
    right: -98%;
}

.accent-70-bgcolor::before {
    content: "";
    width: 100%;
    top: 0;
    bottom: 0;
    background: #FAC196;
    position: absolute;
    left: -98%;
}

.title4 {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 700;
    font-size: 1.25rem;
    color: #0071CE;
}

.quantum-button--tertiary {
    color: #6D6E71;
}

.quantum-button--tertiary.quantum-button--hover,
.quantum-button--tertiary:hover {
    background: transparent;
}

.quantum-button.quantum-button--focus,
.quantum-button:focus {
    box-shadow: none;
}

.text-color-gray {
    color: #6D6E71 !important;
}

ul.list-ul ul {
    list-style: circle;
    margin-left: 2rem;
}

.tab-table.acc-table table td:first-child,
.tab-table.acc-table1 table td:first-child {
    text-align: left;
}

.tab-table.acc-table table td:first-child {
    width: 25%;
}

.tab-table.acc-table70 table td:first-child {
    width: 70%;
    text-align: left;
}

.quantum-drop-down-menu__link {
    padding: 24px 28px;
    text-align: left;
}

.tab-table table th {
    width: 25%;
}

.tab-table table th.bg-none-tab {
    width: 30%;
}

.tab-table table th.bg-tab1 {
    width: 70%;
}

.wd33 {
    width: 33.3%;
}

p.p-ref {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 400;
    font-size: 1rem;
    line-height: 1.3;
    color: #6D6E71;
}

/* .download-a-copy-section.safty-data-dwn {
   border-top: 1px solid #0071CE;
} */
ul.items li.item.active .field-content {
    border-bottom: 1px solid #6D6E71;
    padding-bottom: 2rem;

}

.component.accordion.cnt-custom.initialized li.item.active {
    padding-bottom: 1rem;
}

.component.accordion.cnt-custom.initialized li.item,
.component.accordion.initialized li.item {
    padding: 0 2rem;
}

#cnt-custom.component.accordion.initialized li:first-child,
.component.accordion.cnt-custom.initialized li:first-child,
#cnt-custom.component.accordion.initialized li:nth-child(2),
#cnt-custom.component.accordion.initialized li:nth-child(3),
#cnt-custom.component.accordion.initialized li:nth-child(4) {
    padding-bottom: 0;
}

#cnt-custom.component.accordion.initialized li.item:last-child,
.component.accordion.cnt-custom.initialized li.item:last-child {
    padding-top: 0;
    padding-bottom: 2rem;
}

.tab-table.acc-table-center td {

    width: 50%;
}

/***********************************************************************************************************/
.u_highlight {
    font-weight: bold;
    text-decoration: underline;
    color: #303234;
}

.highlight {
    font-weight: bold !important;
}

.graybox,
.graybox_w70 {
    background: #D9D9D9;
    text-align: center;
    padding: 3.5rem;
    position: relative;
}

.graybox:after {
    content: "";
    background: #D9D9D9;
    width: 1000%;
    right: -1000%;
    position: absolute;
    top: 0px;
    height: 100%;
}

.graybox:before {
    content: "";
    background: #D9D9D9;
    width: 1000%;
    left: -1000%;
    position: absolute;
    top: 0px;
    height: 100%;
}

.graybox .title3,
.graybox_w70 .title3 {
    width: 60%;
    text-align: center;
    margin: 0 auto;
}

.graybox_w70 .title3 {
    width: 70%;
}

.graybox .w-download-btn {
    padding: 2rem 0 0 0px;
}

p.blue-title2.margin-top2.margin-bottom2.text-color-gray {
    font-size: 1.5rem;
    font-weight: 400;
}

#resources-sec>div>div:nth-child(2),
#resources-hcp-sec>div>div:nth-child(1) {
    border-top: 2px solid #0071CE;
}

#resources-hcp-sec {
    margin-bottom: 2rem;
}

#resources-hcp-sec p.blue-text {
    font-size: 1.5rem;
}

.starting-dose-title {
    font-family: 'Futura PT';
    font-style: normal;
    font-weight: 500;
    font-size: 1.5rem;
    line-height: 1.3;
    color: #0071CE;
}

.starting-dose-title-w {
    max-width: 790px;
    margin-left: auto;
    margin-right: auto;
}

.img-center img {
    width: 100%;
}

.starting-dose-title-en {
    max-width: 640px;
}

div#gray-victor-bg {
    background-color: #E7E8E8;
}

#gray-victor-bg .gray-box {
    max-width: 1170px;
    margin: 0 auto;
}

.row.mx-0.text-image-container {
    position: relative;
    max-height: 700px;
    margin-bottom: 2.5rem;
    overflow: hidden;
}

.row.mx-0.text-image-container img {
    max-width: 100%;
}

.position-absolute {
    position: absolute;

}

.position-absolute .container {
    max-width: 1280px;
}

.cus-box-top-btm {
    border-top: 10px solid #0071CE;
    padding: 1.5rem 0;
    border-bottom: 10px solid #0071CE;
    font-size: 1.8rem;
    line-height: 1.4;
    color: #6D6E71;
    font-weight: 700;
}

.cus-box-mid {
    display: flex;
    align-items: center;
    padding: 0 4rem;
}

.cus-box-mid p,
.vic-box p,
.gray-boxs p {
    font-size: 1.2rem;
    line-height: 1.2 !important;
    color: #6D6E71;
}

.gray-boxs p.tit-blue {
    font-size: 1.5rem;
}

.vic-main-box {
    margin-bottom: 3rem;
}

.vic-main-box h3,
.gray-boxs h3 {
    font-size: 1.8rem;
    line-height: 1.4;
    margin-bottom: 2rem;
    color: #6D6E71;
    font-weight: 500;
}

.gray-boxs h3 {
    margin-bottom: 1rem;
}

.gray-boxs {
    background: #f1f1f1;
    padding: 3rem;
}

.vic-box {
    flex-direction: row;
    display: flex;
    align-items: center;
}

.vic-box img {
    margin-right: 2rem;
}

.p-fnt-15,
.vic-box p.p-fnt-15,
.accordion .field-content .normal-fnt p.p-fnt-15,
.cus-box-mid p.p-fnt-15 {
    font-size: 1.5rem;
    line-height: 1.2;
}

.td-bdr-top {
    border-top: solid 4px #80d2ea;
}

#vectbix-victory .p-fnt-15,
#vectbix-victory .vic-box p.p-fnt-15,
#vectbix-victory .accordion .field-content .normal-fnt p.p-fnt-15,
#vectbix-victory .cus-box-mid p.p-fnt-15 {
    font-size: 1.4rem;
}

p.tit-blue.margin-bottom2.p-fnt-15 {
    font-size: 1.5rem !important;
    font-weight: 500;
}

.fnt-4 {
    font-size: 3rem;
    font-weight: 500;
}

.cus-p-value {
    text-align: right;
    font-weight: 500;
    color: #6D6E71;
    line-height: 1;
    font-size: 1.5rem;
    padding-right: 5rem;
}

.btm-br {
    border: 0;
    border-bottom: dotted 1px #6D6E71;
    margin: 2rem auto;
    width: 98%;
}

.p-fnt-12 {
    font-size: 1.2rem;
}

.one,
.two,
.three,
.four {
    display: flex;
    flex-direction: row;
    margin-bottom: 2rem;
    font-size: 1.2rem;
    align-items: center;
}

.one img,
.two img,
.three img,
.four img {
    margin-right: 50px;
}

.tum-img {
    display: flex;
    flex-direction: row;
    align-items: self-start;
    ;
}

.tum-img img {
    margin-right: 30px;
    margin-top: 5px;
}

.tum-img:nth-child(2) img {
    margin-top: 0px;
}

.vic-down {
    font-size: 2.25rem;
    text-align: center;
    line-height: 1.5;
    color: #6D6E71;
}

.vic-down a {
    color: #6D6E71;
}

h2.vic-down.margin-top2.fnt-weg-500 {
    line-height: 1.2;
}

.bg-dos-acc2 {
    background: url('/~/media/FA89E408165649C3BEF84C0E0EDAC8A3.ashx');
    padding-top: 17rem;
    background-repeat: no-repeat;
    background-position: center 0;
    background-size: contain;
}

.bg-dos-acc21 {
    background: url('/~/media/38EE4A783E5448BE891697319CDC00F4.ashx');
    background-repeat: no-repeat;
    background-position: center 0;
    background-size: cover;
}

.desktop-none {
    display: none;
}

.pad-lft-4 {
    padding-left: 4rem
}

.pad-lft-0 {
    padding-left: 0rem
}

.cus-box-top-btm1 {
    border-top: 10px solid #0071CE;
    padding: 1.5rem 0;
    border-bottom: 10px solid #0071CE;
    font-size: 1.5rem;
    line-height: 1.4;
    color: #6D6E71;
    font-weight: 400;
}

.inner-page-banner h1.quantum-banner__title span.fnt-16 {
    font-size: 2rem;
    font-weight: 700;
}

.ml-00 {
    margin-left: 0 !important;
}

.ml-05 {
    margin-left: 10px !important;
}

.fnt-medium,
.accordion .field-content p.fnt-medium {
    font-family: 'Futura PT';
    font-size: 2rem;
    font-weight: 500;
    font-style: normal;
    color: #6D6E71;
}

.align-center {
    align-items: center;
    display: flex;
}

.fnt-weg-500 {
    font-weight: 500 !important;
}

.fnt-700 {
    font-weight: 700;
}

.grayblue {
    color: #1C3849 !important;
    font-size: 1.5rem;
    font-weight: 500 !important;
}

.fnt-12m,
p.blue-text.fnt-12m {
    font-size: 1.5rem;
    font-weight: 400;
    color: #6D6E71;
    line-height: 1.2;
}

.cus-style-box .col-md img {
    margin-bottom: 20px;
}

.cus-style-box .col-md .fnt-12m {
    font-size: 1.3rem;
    font-weight: 400;
    color: #6D6E71;
    line-height: 1.3;
}

.cus-style-box1 .col-lg .fnt-12m {
    font-size: 1.2rem;
    font-weight: 400;
    color: #6D6E71;
    line-height: 1.2;
    font-family: 'Futura PT';
}

.cus-style-box .col-md,
.cus-style-box1 .col-lg {
    text-align: center;
    border-right: dotted 2px #6D6E71;
}

.cus-style-box .col-md:last-child,
.cus-style-box1 .col-lg:last-child {
    border: none;
}

.hr-cus-style {
    border-top: dotted 2px #6D6E71;
    border-bottom: 0;
}

li a {
    color: #6D6E71;
}

#nomargin.cnt-custom {
    margin-top: 0;
}

#pr .quantum-banner__inner {
    padding-bottom: 1%;
}

input.select-all.dwn-bttn {
    margin-right: 2rem;
}

.fnt-300,
.accordion .field-content p.fnt-300 {
    font-weight: 400;
    font-family: 'Futura PT';
}

.fnt-400,
.accordion .field-content p.fnt-400 {
    font-weight: 400;
}

.fnt-12new,
.accordion .field-content p.fnt-12new,
ul.list-ul.gray-li li.fnt-12new {
    font-size: 1.2rem;
    line-height: 1.2;
    font-weight: 400;
}

.tab-table.normal-fnt.th25 table tbody tr th {
    text-transform: uppercase;
}

.fnt-12new.pad-21 {
    padding: 0 20px;
}

.txt-cent {
    text-align: center;
}

.cus-style-box1.txt-lft .col-lg ul li,
.cus-style-box1.txt-lft .col-lg p,
.txt-lft {
    text-align: left !important;
}

.cus-style-box1 .fnt-medium {
    font-family: 'Futura PT';
    font-size: 1.5rem;
    font-weight: 500;
    margin-bottom: 1rem;
    font-style: normal;
    min-height: 66px;

    color: #6D6E71;
    text-align: center;
    line-height: 1;
}

.cus-style-box1.txt-lft .col-lg img {
    margin-bottom: 1rem;
}

.accordion .field-content p.tit-blue {
    font-size: 1.5rem;
    font-weight: 500;
}

.border-0,
.tab-table table td.border-0 {
    border: 0;
}

.normal-fnt p,
.normal-fnt ul li,
.accordion .field-content .normal-fnt p {
    font-weight: 400;
    font-size: 1.2rem;
    text-align: left;
    line-height: 1.2;
}

.tab-table table td.td-no-pad {
    padding: 0 !important;
}

.td-newstyle {
    padding: 1rem;
    width: 100%;
    border-right: 2px solid #0491bc;
    background: url(/~/media/8732D431F191460EA85E4413E1DBC0B1.ashx) no-repeat;
    color: #FFFFFF;
    text-align: center;
    font-weight: 400;
    font-family: 'Futura PT';
    font-style: normal;
    font-size: 1.5rem;
    line-height: 1;
    background-size: cover;
}

.tab-table.normal-fnt table th {
    width: 33.3%;
}

.tab-table.notd table td {
    width: 16.3%;
    color: #6D6E71;
}

.tab-table.normal-fnt.th25 table th {
    width: 25%;
}

.pad-1r {
    padding: 1rem;
}

.dis-blk {
    display: block;
    margin-bottom: 5px;
}

.tab-table.normal-fnt table th.bdr-rgt-th {
    border-right: solid 1px #6d6e71;
}

.tab-table table th.no-bg-th {
    background: none;
    color: #6d6e71;
    border: solid 1px;
}

.p-fnt-12.margin-top2.grays {
    color: #6d6e71;
    font-size: 1.5rem;
}

#study-design-content .popup-title-text {
    width: 98%;
}

.span-white {
    white-space: nowrap;
}

.tst-lower {
    text-transform: lowercase;
}

.white-img-box.mb-20 img[alt="vectibix-fr"] {
    margin-top: 50px;
}

.ltsp1 {
    letter-spacing: 1px;
}

.inner-page-banner h1.quantum-banner__title span.nospace {
    display: inline;
    font-size: inherit;
    font-weight: inherit;
    color: inherit;
    letter-spacing: -7px;
}

span.nospace {
    letter-spacing: -2px;
}

span.nospace1 {
    letter-spacing: -1px;
}

html[lang="fr"] .quantum-drop-down-menu__link {

    font-size: 17px;
    padding: 24.5px 28px;

}

footer#footer ul li a {
    border-bottom: none;
}

#footer-top .component-content ul li:last-child .field-link::after,
footer#footer ul li:last-child .field-link::after {
    content: none;
}

@media (min-width:2000px) {
    .row.mx-0.text-image-container img {
        max-width: 2000px
    }
}

@media (min-width:1400px) {
    .row.mx-0.text-image-container img {
        margin: 0 auto;
        width: 80%
    }

    .l0 {
        text-align: center;
        background: #00a5d5;
    }
}


@media (min-width:768px) and (max-width:1180px) {

    div#moa-md-sec,
    #cnt-custom,
    .cnt-custom {
        margin: 1rem;
    }

    .vectibix-home .row.mx-0.text-image-container {
        margin: 0 0 2.5rem 0;
    }

    .vectibix-home .row.mx-0.text-image-container .col-12 {
        padding: 0;
    }

    .vectibix-home .cnt-custom {
        margin: 0;
    }

    .quantum-header {
        padding: 0 15px;
    }

    html[lang="fr"] #cnt-custom.dosing-bottom-dwn-box {
        margin: 0rem;
    }
}

@media (min-width:768px) and (max-width:1024px) {
    .dosing-bottom-dwn-box {
        margin: 0;
    }

    a.w-bttn.bttn {
        margin-left: 0;
    }

    .cus-box-top-btm {
        font-size: 1.5rem;
    }

    .cus-box-mid {
        padding: 0 2rem;
    }

    #vectbix-victory .p-fnt-15,
    #vectbix-victory .vic-box p.p-fnt-15,
    #vectbix-victory .accordion .field-content .normal-fnt p.p-fnt-15,
    #vectbix-victory .cus-box-mid p.p-fnt-15 {
        font-size: 1.1rem;
    }

    .gray-boxs {
        padding: 3rem 30px;
    }

    .bg-dos-acc2 {
        background-size: 100%;
        padding-top: 9rem;
    }

    .pad-lft-4 {
        padding-left: 2rem;
    }

    .cus-style-box1 .col-lg {

        margin-bottom: 3rem;
    }

    .cus-style-box1 .col-lg:nth-child(2) {
        border: 0;
    }

    .component.accordion.cnt-custom.initialized li.item,
    .component.accordion.initialized li.item {
        padding: 0 0rem;
    }

    h2.vic-down.margin-top2.fnt-weg-500 {
        padding: 0 35px;
    }

    #vectbix-victory .f-note.cnt-custom {
        padding: 1rem 15px;
    }

    .cus-p-value {
        padding-right: 1rem;
        font-size: 1.2rem;
    }

    .tum-img img {
        margin-right: 7px;
    }

    h1.eyebrow {
        font-size: 2rem;
        margin: 2rem 0rem 0;
    }

    #home h1.eyebrow span.bg-fnt {
        font-size: 4rem;
        line-height: 1.5;
    }

    .title.tab-title {
        font-weight: 300;
        font-family: 'Futura PT';
        font-size: 2rem;
    }

    h1.quantum-banner__title,
    h1.quantum-banner__title,
    .title {
        font-size: 2rem;
    }

    .accordion .field-heading,
    .inner-page-banner h1.quantum-banner__title span.fnt-16,
    .fnt-medium,
    .accordion .field-content p.fnt-medium {
        font-size: 1.5rem !important;
    }

    .vic-box {
        margin-bottom: 1rem;
    }

    ul.list-ul li,
    .cus-box-top-btm1,
    .toggle-content ul.list-ul li,
    .fnt-12m,
    p.blue-text.fnt-12m,
    .cus-style-box .col-md .fnt-12m,
    .cus-style-box .col-md .fnt-12m,
    ul.list-ul.tab-ul li,
    ol.list-ol.references-list li,
    .fnt-12new,
    .accordion .field-content p.fnt-12new,
    ul.list-ul.gray-li li.fnt-12new,
    .cus-style-box1 .col-lg .fnt-12m,
    .tab-table table th {
        font-size: 1rem;
    }

    .p-fnt-15,
    .vic-box p.p-fnt-15,
    .accordion .field-content .normal-fnt p.p-fnt-15,
    .cus-box-mid p.p-fnt-15 {
        font-size: 1.1rem;
    }

    .accordion-ul ul li,
    .accordion .field-content p {
        font-family: 'Futura PT';
        font-style: normal;
        font-weight: 400;
        font-size: 1rem;
        line-height: 1;
        color: #6D6E71;
    }

    ol.list-ol.gray-li.margin-top2.references-list {
        padding: 0 15px;
        margin-left: 0;
    }

    .component.accordion.cnt-custom.initialized,
    .component.accordion.initialized {
        padding: 0 15px;
        margin-bottom: 1rem;
    }

    .component.accordion.cnt-custom.initialized li.item.active {
        padding-bottom: 0;
    }

}

@media screen and (min-width: 576px) {

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        border: 0;
    }

    #acc-td-col1 {
        width: 203px;
    }

    #acc-td-col2 {
        width: 42%;
    }

    #acc-td-col3 {
        width: 42%;
    }

    .inner-page-banner .quantum-banner__inner {
        display: block;

        height: auto;
    }

    .quantum-header__left {
        padding-left: 15px;
    }

    .quantum-banner__inner:before {
        display: none;
    }

}

@media screen and (min-width: 1181px) {
    .moa-text {
        padding-left: 50px;
    }
}

@media screen and (min-width: 992px) {

    #home .quantum-banner--multiple-background-images .quantum-banner__inner {
        height: 720px;
    }

    .quantum-header__logo {
        /* max-height: 80px; */
    }

    .dosing-bottom-dwn-box {
        padding: 0 1rem;
    }

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        padding: 3rem;
    }

    footer .quantum-modal__dialog,
    footer .quantum-modal .quantum-modal__dialog {
        padding: 3rem;
        max-width: 54%;
    }

    footer #kyprolis-isi-popup .quantum-modal__dialog,
    footer #kyprolis-isi-popup.quantum-modal .quantum-modal__dialog {
        padding: 3rem;
        max-width: 83%;
    }

    footer #kyprolis-isi-popup {
        text-align: center;
    }

    footer #kyprolis-isi-popup.quantum-modal .quantum-modal__dialog {
        margin: 0 auto;
    }

    .title.victory-program-title {
        padding-right: 7rem;
    }

    .quantum-drop-down-menu__list {
        max-width: 940px;
    }

    .quantum-drop-down-menu__menu-link {
        padding: 0.6rem 1rem;
    }

    #header>div>div.quantum-header__right>div.quantum-header__menu>nav>ul.quantum-drop-down-menu__list li:last-child a {
        padding-right: 0px;
    }

    .title.safety-tab-title {
        margin-right: 4rem;
    }

}

#moa-footer {
    background: #fff;
    padding: 2rem 0px;
}

@media screen and (min-width: 992px) {

    /*.wdd-70 {    width: 74%;
   .wdd-70.prime {    width: 70%;}}*/
    .wd-75 {
        width: 77%;
    }

    .inner-page-banner .quantum-banner__text {
        max-width: 1260px;
        padding: 0 1rem;
    }

    div#patient-resources {
        padding: 0;
    }

    .slide .component-content {
        display: flex;
        align-items: center;

    }

    .inner-page-banner .quantum-banner__inner {
        padding: 3% 0;
        height: auto;

    }

    .quantum-drop-down-menu__menu {
        -webkit-box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
        -moz-box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
        box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);

    }

    .quantum-drop-down-menu__menu {
        padding: 0;
        background: #E5E5E5;
        width: 400px;
        white-space: initial;
    }

    .quantum-drop-down-menu__menu-link {
        padding: 1rem 0;
        margin: 0 1.8rem;
        border-bottom: 1px solid #0071CE;
        white-space: inherit;
    }

    .quantum-drop-down-menu__menu-link:hover,
    a.quantum-drop-down-menu__menu-link.active {
        background: transparent;
        font-weight: 700;
    }

    li.quantum-drop-down-menu__menu-list-item:last-child a.quantum-drop-down-menu__menu-link {
        border: none;
    }

    .quantum-drop-down-menu__list-item--dropdown-visible .quantum-drop-down-menu__link,
    .quantum-drop-down-menu__list-item:hover>.quantum-drop-down-menu__link,
    .quantum-drop-down-menu__link:hover,
    a.quantum-drop-down-menu__link.active {
        background: rgb(109 110 113);
        color: #fff;
    }

    .quantum-header__left {
        padding-left: 0;
    }

    .inner-page-banner .quantum-banner__text {
        padding: 0 5px;
    }

}

@media (min-width:1180px) and (max-width:1180px) {
    .inner-page-banner .quantum-banner__text {
        padding: 0 32px;
    }
}

@media (min-width:1200px) {
    .fnt-13 {
        font-size: 1.3rem !important
    }

    #obu-external-link-canada .quantum-modal__dialog {
        max-width: 700px;
    }

}

@media screen and (max-width: 1200px) {

    .graybox:before {
        width: 20px;
        left: -20px;
    }

    .graybox:after {
        width: 20px;
        right: -20px;
    }

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        margin: 0 1rem;
    }

    .td-col2 {
        flex: 0 0 70%;
    }

    .td-col1 {
        flex: 0 0 30%;
    }

    #obu-external-link .quantum-modal__dialog,
    #obu-external-link .quantum-modal .quantum-modal__dialog {
        margin: 0 auto;
    }

}

@media screen and (max-width: 1024px) {
    .download-mdl {
        max-width: 70%;
    }

    .quantum-drop-down-menu__link,
    .quantum-drop-down-menu__menu-link {
        font-size: 1rem;
        padding: 1rem 0.2rem;
    }

    div#moa-md-right-cnt,
    div#moa-md-right-img {
        padding: 0 15px;
    }

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        margin: 0 auto;
    }

    h1.quantum-banner__title {
        padding: 0 20px;
    }
}

@media(min-width:768px) and (max-width:1024px) {

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        max-width: 70%;
    }

    html[lang="fr"] .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        max-width: 89%;
    }
}

@media screen and (max-width: 991px) {

    .quantum-drop-down-menu__link,
    .quantum-drop-down-menu__menu-link {
        font-size: 1rem;
        padding: 1rem 2rem;
    }

    .blue-box {
        padding: 40px 40px 40px 200px;
    }

    svg.quantum-icon.quantum-button__icon.desktop-break {
        display: none;
    }

    .quantum-header__menu {
        right: 0;
    }

    #top-header .quantum-header__menu {
        display: block;
        position: relative;
        width: auto;
        top: 0;
        right: 0;
        background: transparent;
    }

    #top-header nav.quantum-drop-down-menu {
        border: none;
        background: transparent;
        box-shadow: none;
        margin: 1rem;
    }

    #slider-home .field-slideimage {
        max-width: 400px;
    }

    .slide1-logo {
        margin-top: 1rem;
        max-width: 190px;
    }

    a.download-pdf-lang.dwn-bttn {
        padding: .8rem 3rem;
    }

    .quantum-header__logo {
        padding: 5px 5px 5px 0;
    }

    #dosing-bottom-box {
        padding: 1rem;
    }

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        height: auto;
    }

    #obu-external-link .quantum-modal__dialog,
    #obu-external-link .quantum-modal .quantum-modal__dialog {
        height: auto;
    }

    .select.dwn-pdf {
        border-radius: 0;
        font-size: 1rem;
        height: 40px;
    }

    h1.quantum-banner__title {
        padding: 0;
    }
}

@media screen and (max-width: 767px) {
    #study-design-content .popup-title-text {
        font-size: 1.3rem;
    }

    .blue-box {
        padding: 20px 20px 20px 100px;
        font-size: 20px;
    }

    .blue-box::before {
        height: 60px;
        width: 60px;
        left: 10px;
    }

    html[lang="fr"] footer#footer ul li a {
        font-size: 11px;
    }

    html[lang="fr"] footer#footer .component.link-list.col-12 {
        /* padding: 0; */
    }

    html[lang="fr"] footer#footer ul li .field-link::after {
        /* content: "|"; */
        /* padding: 0 0.1rem; */
    }

    /*home*/
    #home .bg-img-section {
        order: 2;
    }

    #home .position-absolute {
        position: inherit;
        padding: 0;
    }

    .row.mx-0.text-image-container {
        margin: 0;
    }

    #home .position-absolute .container {
        padding: 0;
    }

    #external-popup button.blue-btn {
        width: 100%;
    }

    li.quantum-drop-down-menu__top-nav-list-item.home-icon {
        display: none;
    }

    .mb-none {
        display: none;
    }

    .desktop-none {
        display: block;
    }

    #lang-switch .mb-none {
        display: inline-block;
    }

    .mb-mr-btm-30 {
        margin-bottom: 30px;
    }

    .download-mdl {
        max-width: 60%;
    }

    #moa-md-right-img>div {
        width: 300px;
    }

    h1.quantum-banner__title {
        font-size: 2.25rem;
        line-height: 1.3;

    }

    .quantum-header__left {
        width: 110px;
    }

    #home .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {
        height: 40px;
    }

    #home h1.quantum-banner__title {
        padding: 0rem 1rem 5rem;
    }

    .slide-title,
    p.blue-text,
    .median-time,
    .how-to-take-lumakras-des ul li,
    .victory-program-gray-box ul li,
    .recommended ul li,
    .blue-title2,
    .pai-graph-title,
    .moa-text ul li,
    .study-design-p,
    .accordion-ul ul li,
    .accordion .field-content .study-design-yellow-bg p,
    .title.graph-title,
    .accordion .field-heading,
    .td-head,
    .acc-td-head,
    .popup h2,
    .content,
    .inner-page-banner h1.quantum-banner__title span,
    ul.list-ul li {
        font-size: 1.2rem;
    }

    .fnt-medium,
    .accordion .field-content p.fnt-medium {

        font-size: 1.5rem;

    }

    ol.list-ol {
        list-style-type: decimal;
        margin-left: 1rem;
    }

    ul.list-ul {
        list-style: disc;
        margin-left: 1rem;
    }

    ol.list-ol.references-list li {
        font-size: 1rem;
        font-family: 'Futura PT';
        line-height: 1.3;
    }

    .cus-box-mid {
        display: flex;
        align-items: center;
        padding: 0 15px;
        margin-top: 1rem;
    }

    .vic-box,
    ul.list-ul.gray-li.margin-top2.ml-05.top-201 {
        margin-bottom: 1rem;
    }

    .align-center {
        align-items: center;
        display: block;
    }

    ul.list-ul.gray-li li,
    .p-fnt-15,
    .vic-box p.p-fnt-15,
    .accordion .field-content .normal-fnt p.p-fnt-15,
    .cus-box-mid p.p-fnt-15,
    .cus-box-top-btm {
        font-size: 1rem;
    }

    .cus-box-top-btm {
        font-size: 1.3rem;
    }

    .cus-p-value {
        padding-right: 0rem;
        font-size: 1rem;
    }

    .one,
    .two,
    .three,
    .four {
        display: block;
        text-align: center;
    }

    .pad-lft-0 {
        padding-left: 15px;
    }

    .one .p-fnt-15,
    .two .p-fnt-15,
    .three .p-fnt-15 {
        border-bottom: dotted 2px #6D6E71;
        padding-bottom: 10px;
    }

    .tum-img {
        margin-bottom: 1rem;
        text-align: left;
    }

    .p-fnt-12 {
        font-size: 1rem;
    }

    ul.list-ul.gray-li.top-201 li:before {
        top: 15px;
    }

    .vic-down {
        padding: 0 15px;
        font-size: 1.5rem;
    }

    #vectbix-victory .f-note.cnt-custom {
        padding: 0 15px;
        margin-bottom: 1rem;
    }

    .cus-style-box .col-md,
    .cus-style-box1 .col-md {
        text-align: center;
        border: 0;
        margin-bottom: 1rem;
        padding-bottom: 1rem;
        border-bottom: dotted 2px #6D6E71;
    }

    .cus-style-box1 .col-lg {
        text-align: center;
        border-bottom: dotted 2px #6D6E71;
        border-right: 0;
        padding-bottom: 1rem;
        margin-bottom: 1rem;
    }

    .bg-dos-acc2 {
        background: url('/~/media/2E1D58CDFDCB4B7AB9FDA570A51493EA.ashx');
        background-repeat: no-repeat;
        padding: 3rem 0 0;
        background-size: contain;
    }

    .bg-dos-acc2 .desktop-none {
        display: block;
    }

    .pad-lft-4 {
        padding-left: 15px;
    }

    .cus-style-box1 .fnt-medium {
        min-height: auto;
    }

    .component.accordion.cnt-custom.initialized li.item.active {
        padding-bottom: 0;
    }

    #vectbix-victory .cus-box-mid p.p-fnt-15 {
        font-size: 1rem;
        margin-bottom: 1rem;
    }

    .gray-boxs {
        background: #f1f1f1;
        padding: 1rem 15px;
    }

    p.tit-blue.margin-bottom2.p-fnt-15 {
        margin-top: 1rem;
    }

    #vectbix-victory .p-fnt-15,
    #vectbix-victory .vic-box p.p-fnt-15 {
        font-size: 1rem;
    }

    .vic-main-box h3,
    .gray-boxs h3 {
        font-size: 1.5rem;
        line-height: 1.4;
        margin-bottom: 1rem;
        color: #6D6E71;
        font-weight: 500;
        margin-top: 1rem;
    }

    .title.tab-title {
        font-size: 1.5rem;
    }

    .tabs-container .title.tab-title {
        font-weight: 400;
        font-size: 1.5rem;
    }

    .margin-top3 {
        margin-top: 1rem;
    }

    .f-note,
    .accordion .field-content p.f-note-small {
        font-family: 'Futura PT';
        font-style: normal;
        font-weight: 300;
        font-size: .80rem;
    }

    .component.accordion.cnt-custom.initialized,
    .component.accordion.initialized {
        padding: 0 15px;
        margin-bottom: 2rem;
        margin-top: 2rem;
    }

    .mb-mar-btm-1 {
        margin-bottom: 1rem
    }

    .toggle-content ul.list-ul li {
        font-size: 1rem;
    }

    div#cnt-custom.component.accordion.initialized {
        margin: 2rem auto;
    }

    .accordion-ul ul li,
    .accordion .field-content p {
        font-family: 'Futura PT';
        font-style: normal;
        font-weight: 400;
        font-size: 1rem;
        line-height: 1.3;
        color: #6D6E71;
    }

    .inner-page-banner h1.quantum-banner__title span.fnt-16,
    .cus-box-top-btm1 {
        font-size: 1rem;

    }

    .margin-bottom31 {
        margin-bottom: 1rem;
    }

    .fnt-12m,
    p.blue-text.fnt-12m,
    .cus-style-box .col-md .fnt-12m {
        font-size: 1rem;

        line-height: 1.3;
    }

    .p-new {

        font-size: 1rem;
    }

    .component.accordion.cnt-custom.initialized li.item,
    .component.accordion.initialized li.item {
        padding: 0;
    }

    ul.list-ul ul {
        list-style: circle;
        margin-left: 0rem;
    }

    .title,
    h1.quantum-banner__title,
    .blue-title3,
    .home-banner-text,
    h1.eyebrow,
    #home .quantum-banner__title,
    .download-a-copy-section-title,
    .title3,
    ul.list-ul.box-align-center li {
        font-size: 1.5rem;
    }

    h1.quantum-banner__title {
        font-size: 1.5rem;
        padding-top: 1rem !important;
    }

    #home h1.eyebrow {
        font-size: 1.5rem;
    }

    #download-a-copy-section::before,
    #download-a-copy-section-accent-90::before {
        width: 20px;
    }

    .home-banner-text,
    #home .quantum-banner__title,
    h1.eyebrow {
        margin: 1.5rem 0rem 0;
    }

    #home h1.eyebrow span.bg-fnt {
        font-size: 2rem;
        line-height: 1.5;
    }

    .dor.line.title-flex p {
        line-height: 1.5;
    }

    .quantum-banner--multiple-background-images .quantum-banner__inner {
        padding: 5% 1rem;
    }

    .tabs .component-content .tabs-inner .tabs-heading,
    .tabs .component-content .tabs-inner .tabs-container .tab,
    .tabs-container .component.content.col-12 {
        padding: 0;
    }

    .tabs .component-content .tabs-inner .tabs-heading {
        white-space: initial;
    }

    .field-content,
    .title.graph-title {
        margin-top: 2rem;
    }

    .tabf-table-td,
    .tabf-top-table-td,
    .td-des,
    .td-head,
    .acc-td-des,
    .acc-td-des ul li,
    .tab-table table td,
    .tab-table table th {
        font-size: 1rem;
    }

    .tabf-table-tr {
        border-bottom: 2px solid rgba(0, 0, 0, 0.04);
    }

    .quantum-header__menu {
        right: 0;
    }

    #top-header nav.quantum-drop-down-menu {
        margin: 0;
        height: 100%;
    }

    li.quantum-drop-down-menu__top-nav-list-item a {
        font-weight: 500;
        padding-right: 10px;
    }

    html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item a {
        font-weight: 500;
        padding-right: 7px;
        padding-top: 0;
        padding-right: 7px;
        padding-bottom: 0;
    }

    html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item a {
        font-size: 0.65rem;
    }

    html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item a:after {
        display: none;
    }

    html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item a#lang-switch-en {
        display: inline-flex;
    }

    html[lang="fr"] li.quantum-drop-down-menu__top-nav-list-item a#lang-switch-en::before {
        content: '|';
    }

    html[lang="fr"] #lang-switch-en .mb-none {
        display: inline-block;
        padding-right: 0;
        padding-left: 5px;
    }

    html[lang="fr"] #lang-switch {
        display: none;
    }

    li.quantum-drop-down-menu__top-nav-list-item a.english-lang {
        padding-right: 5px;
    }

    .quantum-button--large.quantum-button--icon-only {
        width: 60px;
    }

    ul.quantum-drop-down-menu__top-nav-list li:first-child a::after,
    a.pipe.logout-text::after,
    .home-icon.pipe a::after,
    li.quantum-drop-down-menu__top-nav-list-item.french-lang a::after {
        display: none;
    }

    a.pipe::after {
        padding: 0;
        padding-left: 0.3rem
    }

    .quantum-header__menu {
        max-width: 768px;
    }

    li.quantum-drop-down-menu__list-item {
        border-bottom: 2px solid rgba(0, 0, 0, 0.04);
    }

    .callout {
        margin-right: 0;
    }

    .how-to-take-lumakras {
        flex-wrap: wrap;
    }

    .how-to-take-lumakras-cnt {
        width: 100%;
        margin: 0rem 0 3rem;
    }

    .dosing-kras::before,
    .dosing-kras:after {
        height: 5px;
    }

    .dosing-kras {
        padding: 0.5rem 1rem;
        border-top: 5px solid #EB2244;
        border-left: 5px solid #EB2244;
        border-bottom: 5px solid #EB2244;
        border-radius: 20px 0 0 20px;
        max-width: 400px;
        width: 70%;
    }

    .drug-interactions-top-title {
        margin: 0px 0rem 2rem;
    }

    .drug-interactions-td.gray-bg.drk {
        width: 82%;
    }

    .dose-modification-recommended,
    .dose-modification-f-note {
        margin-top: 3rem;
    }

    .alternative-dosing-method.line::before {
        min-height: 90px;
        height: 81%;
    }

    .alternative-dosing-method {
        width: 90%;
    }

    h1.quantum-banner__title {
        padding: 0 1rem;
    }

    .model-popup-patient-resources {
        overflow: scroll;
    }

    form#patient-resources-obu-kyp {
        top: 0;
        left: 50%;
        transform: translate(-50%, 3%);
        width: 90%;
        padding: 1rem;
    }

    .pai-graph-content,
    .graph-content {
        display: block;
    }

    .pai-graph-img1 {
        margin: 0 auto;
        max-width: 370px;
    }

    .quantum-header__logo {
        padding: 0.23rem 0;
    }

    .quantum-banner,
    .moa-sec1,
    #dosing-bottom-box,
    .graph-img {
        margin-bottom: 2rem;
    }

    .moa-sec1 {
        margin-top: 1rem;
    }

    .quantum-banner {
        margin-bottom: 0rem;
    }

    .pai-graph-table,
    .pai-graph-table,
    .graph-right-text,
    #dosing-bottom-box,
    .study-design-f-note {
        margin-top: 3rem;
    }

    .Send-to-patient.dwn-bttn.model-pop-up-open,
    .Send-to-patient.dwn-bttn.model-pop-up-open,
    .study-design-btn {
        margin: 2rem auto 0;
    }

    .patient-group-td {
        padding: 0.6rem;
    }

    .download-dropdown {
        margin-top: 0;
    }

}

@media screen and (max-width: 720px) {
    #home .quantum-banner__title {
        max-width: 310px;
    }

    .tab-table table td {
        padding: 1rem .5rem;
    }

    .margin-top4 {
        margin-top: 2rem;
    }

    h1.quantum-banner__title {
        padding: 0px 10px;
    }

    .graybox .title3,
    .graybox_w70 .title3 {
        width: 100%;
    }

    .graybox,
    .graybox_w70 {
        padding: 2rem;
        margin-bottom: 4rem;
    }

    .graybox_w70 a.p-bttn.bttn,
    .graybox a.p-bttn.bttn {
        margin-left: 0;
    }
}

@media screen and (max-width: 640px) {

    html[lang="fr"] #kyprolis-isi-popup .title {
        font-size: 1.5rem;
    }

    html[lang="fr"] #kyprolis-isi-popup p.primary,
    html[lang="fr"] #kyprolis-isi-popup .isi-ul li,
    html[lang="fr"] #kyprolis-isi-popup p.pop-p.margin-top1 {
        font-size: 1rem;
    }

    .component.rich-text.cnt-custom p.f-note.dgrays {
        padding: 10px;
    }

    .model-popup-patient-resources {
        height: 100%;
    }

    .inner-page-banner .download-section .download-title.title {
        padding-right: 0;
    }

    .download-mdl {
        max-width: 100%;
    }

    #slider-home .field-slideimage,
    #slider-home .field-slideimage img {
        max-width: 100%;
        width: 100%;
    }

    .download-a-copy-section-title .download-a-copy-section-group .bttn-align-mdl {

        justify-content: center;
        margin: 1rem 0;
    }

    .tab-table {
        overflow-x: scroll;
    }

    #home h1.quantum-banner__title {
        background: rgb(0 0 0 / 61%);
        padding: 1rem;
    }

    .accordion .field-heading {
        padding-right: 2.2rem;
    }

    .icon {
        flex: 0 0 80px;
    }

    .icon-text {
        flex: 0 0 80%;
    }

    .icon.icon-tyle2 {
        flex: 0 0 160px;
    }

    .icon-text.icon-text2 {
        flex: 0 0 55%;
    }

    .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        height: auto;
    }

    #obu-external-link .quantum-modal__dialog,
    #obu-external-link .quantum-modal .quantum-modal__dialog {
        height: auto;
    }

    .sp-only {
        display: block;
        padding: 1rem;
    }

    .pc-only,
    #footer-top .component-content ul li a::after,
    footer#footer ul li a::after {
        display: none;
    }

    #home .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {
        height: 34px;
    }

    .slide .component-content {
        display: flex;
        flex-wrap: wrap;
    }

    #slider-home .slide-info {
        width: 100%;
    }

    .carousel-inner .field-slidetext,
    #slider-home li.slide .component.content.col-12,
    .tabs .component-content .tabs-inner .tabs-heading li .component.content {
        padding: 0;
    }

    /* h1.quantum-banner__title {
       padding: 0rem 0rem 3rem;
   } */
    .bttn {
        width: 100%;
        margin: 0;
    }

    .study-design.bttn {
        margin-bottom: 1.5rem;
    }

    .learn-about-codebreak {
        margin-top: 1rem;
    }

    .popup-title,
    .download-a-copy-section-group,
    .safety-tab3,
    .btn-group {
        display: block;
    }

    .title-icon {
        margin-right: 0.5rem;
        width: 100px;
        height: 100px;
        margin: 0 auto 2rem;
    }

    .popup-title-text {
        width: 90%;
    }

    .quantum-modal__dialog {
        padding: 48px 1rem 24px
    }

    .patient-td {
        padding: 0.5rem;
        font-size: 1rem;
    }

    .patient-dem-table {
        margin: 1rem 0 1rem 1rem;
    }

    .tab3-table1 {
        width: 100%;
    }

    div#moa-md-sec,
    #cnt-custom,
    .cnt-custom {
        margin: 0 auto;
    }

    #dosing-bottom-box .title {
        padding: 1rem 0;
    }

    .gray-bg.round-corner {
        padding: 2rem 1rem;
        border-radius: 10px;
    }

    #footer-amgen-logo img {
        margin: 2rem auto;
        display: block;
    }

    #footer-top .component-content ul,
    footer#footer ul,
    .footer-logos,
    #footer-top .component-content {
        justify-content: center;
    }

    footer#footer ul {
        flex-wrap: wrap;
        border-bottom: none;
    }

    #footer-top .component-content .isi-ul ul,
    footer#footer .isi-ul ul {
        text-align: left;
    }

    footer#footer ul li a,
    #footer-top .component-content ul li a {
        font-size: 1rem;
        font-weight: 600;
    }

    .footer-content p {
        font-size: 1rem;
        text-align: center;
    }

    footer#footer {
        padding: 1rem 0 2rem;
    }

    #footer-top .component.link-list {
        order: 2;
        margin-bottom: 0.5rem;
    }

    .callout-img {
        width: 130px;
    }

    .tabs .component-content .tabs-inner .tabs-heading li.active,
    .tabs .component-content .tabs-inner .tabs-heading li.active:hover,
    .tabs .component-content .tabs-inner .tabs-heading li,
    .tabs .component-content .tabs-inner .tabs-heading li:last-child,
    .tabs .component-content .tabs-inner .tabs-heading li:first-child {
        border-radius: 0;
    }

    .tabs .component-content .tabs-inner .tabs-heading {
        flex-wrap: wrap;

    }

    .tabs .component-content .tabs-inner .tabs-heading li {
        width: 100%;
    }

    .tabs .component-content .tabs-inner .tabs-heading li:first-child,
    .tabs .component-content .tabs-inner .tabs-heading li:last-child {
        margin: 0.5rem 0 0;
    }

    ul.tabs-heading li {
        margin: 0.5rem 0 0;
    }

    .download-pdf-main,
    .download-dropdown {
        display: block;
    }

    .download-thumbnail {
        margin: auto auto 1rem;
        width: 60%;
    }

    select.dwn-pdf {
        max-width: 100%;
    }

    a.download-pdf-lang.dwn-bttn {
        padding: 1rem 0;
        text-align: center;
        margin: 1rem 0 0;
        display: block;
    }

    .download-btn-select-all .dwn-bttn {
        flex: 0 0 100%;
        margin: 0.3rem 0;
    }

    .download-btn-select-all {
        display: flex;
        flex-wrap: wrap;
    }

    .contacts-from-td {
        flex: 0 0 98%;
    }

    .td-col1,
    .td-col2 {
        flex: 0 0 50%;
    }

    .nowrap {
        white-space: break-spaces;
    }

    .victory-program #dosing-bottom-box .w-download-btn a,
    a.w-bttn.bttn {
        border-radius: 0;
        margin: .5rem 0;
    }

    a.w-bttn.bttn {
        margin: .5rem 0;
    }

    div#footer-bottom-top-logo {
        width: 100%;
    }

    /* #footer-top .component-content ul, footer#footer ul {
       display: block;
       text-align: center;
   }*/
    #footer-top .component-content ul {
        margin: 1rem 0 0;
    }

    footer#footer ul li a,
    #footer-top .component-content ul li a {
        padding: 0.5rem 0;

    }

    footer#footer ul li a {

        font-size: 10px;

        letter-spacing: -0.2px;
    }

    footer#footer .field-link {
        border-bottom: none;
    }

    #obu-external-link .quantum-modal__dialog,
    .quantum-modal .quantum-modal__dialog {
        margin: 0 1rem;
    }

    .starting-dose-title {
        font-size: 1.2rem;
    }

    .starting-dose-title-en br {
        display: none;
    }

    .starting-dose-title-w br {
        display: none;
    }

    .download-dropdown fieldset {
        display: block;
    }
}


@media screen and (max-width: 480px) {

    /* #home .quantum-banner--multiple-background-images .quantum-banner__inner {
       height: 180px;
   } */
    .callout-img {
        width: 100px;
    }

    a#lang-switch,
    a.lang.quantum-drop-down-menu__top-nav-link {
        width: 180px;
    }

    /* footer#footer ul li a, #footer-top .component-content ul li a {
       font-size: .8rem;

   } */
    .acc-td-col1 {
        width: 24%;
    }

    .acc-td-des ul {
        margin-left: 0.7rem;
    }

    .acc-td-des ul li {
        word-break: break-word;
    }

}

@media screen and (max-width: 375px) {

    #home .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {

        background: url(../images/home-page/banner-bottom-mobile.svg) no-repeat;
        width: 100%;
    }

    .callout-img {
        width: 80px;
    }

    .acc-td-col1 {
        width: 32%;
    }
}

@media screen and (max-width:359px) {
    footer#footer ul li a {
        font-size: 9px;
        letter-spacing: -0.4px;
    }
}