body {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 500;
  font-size: 16px;
  line-height: 1.5;
  margin: 0;
  overflow-y: scroll !important;
  overflow-x: hidden !important;
}

/* .download-btn-select-all, .download-section {
    max-width: 1280px;
    margin: 0 auto;
} */
.download-btn-select-all,
.download-section,
#main-cnt,
.inner-page-banner > div.row.component.column-splitter,
.component.carousel,
#footer-top > .component-content,
div#moa-md-sec,
#cnt-custom,
#footer .component.container.col-12,
.banner .quantum-banner__text,
div#video-bottom-text,
.inner-page-banner .quantum-banner__text,
.dosing-c-border,
.download-btn-select-all,
.download-section,
ul.tabs-heading,
.tabs-container,
#patient-resources,
#cnt-custom-2 {
  max-width: 1280px;
  margin: 0 auto;
}
.download-btn-select-all,
.download-section {
  max-width: 1250px;
}
form#patient-resources-obu-lmk {
  position: absolute;
  max-width: 1100px;
  background: #fff;
  padding: 2rem;
  margin: auto;
  display: block;
  top: 50%;
  left: 50%;
  transform: translate(-50%, -50%);
  width: 90%;
}
.popup-title.cnt-frm {
  align-items: center;
}
.model-popup-patient-resources {
  position: fixed;
  width: 100vw;
  height: 100vh;
  background: rgb(0 0 0 / 65%);
  z-index: 999;
  display: block;
  top: 50%;
  left: 50%;
  transform: translate(-50%, -50%);
  width: 100%;
  margin: auto;
  display: none;
}
#patient-resources-obu-lmk input,
#patient-resources-obu-lmk textarea {
  border: 1px solid #bec3c5;
  padding: 0.6rem;
  border-radius: 3px;
}
textarea#email-body {
  resize: vertical;
  height: 90px;
}
.email-details {
  display: flex;
  flex-wrap: wrap;
  justify-content: space-between;
  margin: 2rem 0;
}
.frm-td {
  display: grid;
  margin-bottom: 1rem;
}
.hidden-fld {
  display: none;
}
.frm-td label {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 500;
  font-size: 1rem;
  line-height: 1.5;
  color: #212426;
}
.contacts-from-td.frm-tr {
  width: 100%;
  flex: 0 0 100%;
}
.contacts-from-td {
  flex: 0 0 48%;
}
small.error-msg {
  display: none;
  color: #e40000;
  font-size: 0.8rem;
  width: 100%;
}
select#dwn-pdf {
  margin-right: 1rem;
}
.download-btn-select-all {
  margin: 2rem auto;
}
.primary-font p.primary,
.victory-program-gray-box ul li {
  font-family: "Roboto" !important;
}
.isi-text1 p {
  font-family: "Open Sans";
}
u.primary.isi-blod {
  font-weight: 700;
  margin-top: 2rem;
  margin-bottom: 0.5rem;
  display: inline-block;
}
p.primary-padding-top {
  padding: 0.1rem !important;
}
#p-top {
  padding-top: 1.5rem;
}
/* .victory-program #dosing-bottom-box .title {
    font-family: 'Montserrat';
} */
.victory-program #dosing-bottom-box .w-download-btn a {
  border-radius: 0;
}
.victory-program .title.main-text {
  max-width: 67%;
  margin: 0 auto;
}
.dwn-bttn {
  cursor: pointer;
  padding: 0.8rem 2rem;
  background: #1e5680;
  border: none;
  font-family: "Roboto";
  font-style: normal;
  font-weight: 600;
  font-size: 1rem;
  line-height: 1.2;
  text-decoration: none;

  text-align: center;

  color: #ffffff;
}
.download-section {
  border-bottom: 2px solid #ccc;
  padding: 2.5rem 0;
  position: relative;
}
.download-section input[type="checkbox"] {
  position: relative;
  border: 2px solid #00619d;
  border-radius: 2px;
  background: none;
  cursor: pointer;
  line-height: 0;
  margin: 0 0.6em 0 0;
  outline: 0;
  padding: 0 !important;
  vertical-align: text-top;
  height: 35px;
  width: 35px;
  -webkit-appearance: none;
  opacity: 0.5;
}

.download-section input[type="checkbox"]:hover {
  opacity: 1;
}

.download-section input[type="checkbox"]:checked {
  background-color: #00619d;
  opacity: 1;
}

.download-section input[type="checkbox"]:before {
  content: "";
  position: absolute;
  right: 50%;
  top: 50%;
  width: 8px;
  height: 20px;
  border: solid #fff;
  border-width: 0 3px 3px 0;
  margin: -1px -1px 0 -1px;
  transform: rotate(45deg) translate(-50%, -50%);
  z-index: 2;
}
.download-check-box {
  display: inline-flex;
  justify-content: flex-end;
  width: 100%;
  position: absolute;
}
.download-check-box fieldset {
  font-size: 0;
}

.download-check-box label {
  font-size: 0;
}
.download-thumbnail {
  background: transparent;
  max-width: 200px;
  flex: 0 0 200px;
  width: 20%;
  margin-right: 2rem;
}
#widget-3 {
  margin-bottom: 3rem;
}
a.download-pdf-lang.dwn-bttn {
  margin-left: 1rem;
  display: flex;
  align-items: center;
  padding: 0 5rem;
}
select.dwn-pdf {
  max-width: 390px;
  width: 100%;
  border: 1px solid #1e5680;
  padding: 0.8rem 0.5rem;
}
.download-pdf-main {
  display: flex;
  align-items: center;
}
.download-description {
  max-width: 800px;
  width: 80%;
  padding: 0.5rem 2rem;
}
.download-dropdown {
  display: flex;
  width: 100%;
}
.download-mdl {
  display: flex;
  flex-wrap: wrap;
}
.download-dropdown fieldset {
  display: flex;
  width: 100%;
}

.download-dropdown legend {
  font-size: 0;
}

.quantum-header__left {
  width: 190px;
}
.quantum-header__logo {
  width: 100%;
  padding: 0px;
  max-height: inherit;
}
div#header {
  background: #f2f2f2;
  -webkit-box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
  -moz-box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
  box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
  border-bottom: 3px solid #ffa400;
}

.quantum-drop-down-menu__link,
.quantum-drop-down-menu__menu-link {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 500;
  font-size: 1.125rem;
  line-height: 1.2;
  color: #1e5680;
}
div#main-cnt {
  padding: 0 15px;
}
p.blue-text {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
  padding: 1rem 0;
}
.title {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 700;
  font-size: 2.25rem;
  line-height: 1.2;

  color: #1e5680;
}
.title span {
  font-weight: 400;
}
.title-flex {
  display: flex;
}
.subhead {
  display: none;
}
.moa-md-sec {
  margin: 1rem 0;
}
.inner-page-banner > div.row.component.column-splitter {
  align-items: center;
}
div#moa-md-right-img,
div#moa-md-sec div {
  padding: 0;
}
.moa-md-sec p {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
}
span.line {
  padding: 0 0.5rem;
  color: #fff;
}
span.line::before {
  display: none;
}
/* .line::before {
    content: "";
    width: 20px;
    display: inline-block;
    color: #EB2244;
    background: #EB2244;
    border-radius: 20px;
    padding: 10px 0;
    margin: 0.3rem 1rem 0.3rem 0;
} */

.line::before {
  content: "";
  width: 1px;
  color: #eb2244;
  background: #eb2244;
  border-radius: 20px;
  padding: 0 7px;
  margin: 0.5rem 1rem 0.5rem 0;
  height: auto;
  position: relative;
}
.gray-bg {
  background: #ffa400;
  padding: 0.5rem 1rem;
  margin: 0rem 0;
}
.gray-bg p {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.5;
  color: #000;
  padding: 0.5rem 0;
}
.gray-bg p a {
  color: #1e5680;
  text-decoration: none;
}
sup {
  vertical-align: super;
  font-size: 60%;
}
.slide .component-content {
  display: flex;
  align-items: center;
}

.carousel-inner li.slide {
  padding: 2rem 1rem;
}
.component.carousel {
  background: #73bca8;
  position: relative;
}
.carousel .carousel-inner {
  background: rgba(255, 255, 255, 0.9);
}
.carousel-inner .nav {
  position: absolute;
  right: 2rem;
  bottom: 1rem;
}
.carousel-inner .nav .sxa-bullets {
  width: 0.9rem;
  height: 0.9rem;
  border-radius: 50%;
  background: #1e5680;
  margin: 0.2rem;
  cursor: pointer;
  opacity: 0.5;
}
.carousel-inner .field-slidetext {
  padding: 1rem 2rem;
}
.slide1-logo {
  margin-top: 3rem;
  max-width: 300px;
}
.slide-title {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 2.25rem;
  line-height: 1.2;
  color: #1e5680;
  padding: 1rem 0;
}
.slide-title a {
  color: #1e5680;
  text-decoration: underline;
}
.slide-title span {
  font-weight: 600;
}
.carousel-inner .nav .sxa-bullets.active {
  opacity: 1;
}
#footer-top > .component-content {
  padding: 1rem;
}
.carousel-inner .nav .nav-items {
  display: flex;
  align-items: center;
  justify-content: space-between;
}
div#moa-md-sec,
#cnt-custom,
#cnt-custom-2 {
  margin: 2rem auto;
}

#footer-top {
  background: #f2f2f2;
  position: relative;
  margin-top: 4rem;
  padding: 0;
}
#footer-top .component-content {
  display: flex;
  justify-content: space-between;
  align-items: center;
  flex-wrap: wrap;
}
#footer-top .component-content ul,
footer#footer ul {
  display: flex;
}
#footer-top .component-content ul li a {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 0.875rem;
  line-height: 1.1;
  color: #1e5680;
  text-decoration: none;
}
#footer-top .component-content ul li a::after,
footer#footer ul li a::after {
  content: "|";
  padding: 0 0.5rem;
}

footer#footer ul li:last-child a::after,
#footer-top .component-content ul li:last-child a::after {
  display: none;
}
#footer-top .component-content ul li a:hover {
  text-decoration: underline;
}

.footer-logos {
  display: flex;
  align-items: baseline;
  justify-content: flex-end;
  width: 100%;
  margin-bottom: 1.2rem;
}
img.ml-32 {
  height: 80px;
}
footer#footer {
  background: #0063c3;
  padding-bottom: 1rem;
}
#footer-amgen-logo img {
  width: 164px;
  margin: 2rem 0;
}
footer#footer ul li a {
  font-family: "Helvetica";
  font-style: normal;
  font-weight: 400;
  font-size: 0.875rem;
  line-height: 1.1;
  color: #ffffff;
  text-decoration: none;
}
.quantum-banner {
  position: relative;
  margin-bottom: 3rem;
}

.home-banner-text,
#home .quantum-banner__title {
  max-width: 570px;
  margin: 4rem 0 0;
  font-family: "Roboto";
  font-style: normal;
  font-weight: 300;
  font-size: 3.25rem;
  line-height: 1.3;
  color: #fff;
  padding: 0 1rem;
}
p.no-padding,
.no-padding {
  padding: 0;
}
/* #home .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after{
    content: "";
    display: inline-block;
    background: url(../images/home-page/banner-bottom.svg) no-repeat;
    width: 100%;
    height: 67px;
    padding: 0 0.625rem;
    background-size: 100%;
    position: absolute;
    bottom: -5px;
    left: 0;
} */
/* .inner-page-banner .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after{
    content: "";
    display: inline-block;
    background: url(../images/mechanism-of-action/banner-bottom.png) no-repeat;
    width: 100%;
    height: 67px;
    padding: 0 0.625rem;
    background-size: 100%;
    position: absolute;
    bottom: -5px;
    left: 0;
} */
#orange-bottom-box #cnt-custom {
  margin: 0 auto;
}
div#top-header {
  padding: 0px;
  background: #0063c3;
}
#footer img.ml-32.Paab-logo {
  height: 46px;
  margin-right: 2rem;
}
#footer-copy-text {
  padding: 0;
  margin: 1rem 0;
}
.footer-content p {
  font-family: "Helvetica";
  font-style: normal;
  font-weight: 400;
  font-size: 0.875rem;
  line-height: 1.4;
  color: #ffffff;
}
#footer .component.container.col-12 {
  padding: 0;
}
#footer > .component.container.col-12 {
  padding: 0 15px;
}
/* footer#footer div {
    padding: 0px;
} */
.quantum-banner__inner {
  max-width: 100%;
}
.banner .quantum-banner--multiple-background-images .quantum-banner__inner {
  max-width: 100%;
  padding: 0;
  display: block;
}

.callout {
  display: flex;
  justify-content: flex-end;
  margin-right: 1rem;
}

h1.quantum-banner__title {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 300;
  font-size: 3.25rem;
  line-height: 1.3;
  color: #ffffff;
  text-align: left;
  margin-bottom: 0;
}
#footer-bottom-top-logo > div > a {
  width: 200px;
  height: 49px;
}
#footer-bottom-top-logo > div > a img {
  width: 100%;
  height: auto;
}

body > div.row.component.column-splitter > div:nth-child(1),
body > div.row.component.column-splitter > div:nth-child(2),
div#moa-md-right-cnt {
  padding: 0;
}

div#moa-md-right-img > .component-content {
  display: flex;
  justify-content: flex-end;
}
ul.quantum-drop-down-menu__top-nav-list {
  display: flex !important;
  align-items: center;
  border: none;
  margin-right: 1rem;
}
li.quantum-drop-down-menu__top-nav-list-item a {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 500;
  font-size: 0.75rem;
  line-height: 1;
  color: #ffffff;
  text-decoration: none;
}
.quantum-drop-down-menu__top-nav-link {
  padding: 12px 6px;
}
ul.quantum-drop-down-menu__top-nav-list li:first-child a::after {
  content: "\7c";
  padding: 0 0.5rem 0 0.5rem;
}
#top-header a.quantum-header__logo.d-block.d-sm-none.gtm-header {
  padding: 0.5rem 0;
}
.vidoe-mrg {
  margin: 2rem 0;
}
a.pipe::after {
  content: "\7c";
  padding: 0 0.5rem;
}
a#lang-switch,
a.lang.quantum-drop-down-menu__top-nav-link {
  color: #fff;
  text-decoration: none;
  /* padding-left: .5rem; */
}
.quantum-drop-down-menu__top-nav-link li a {
  text-decoration: none;
}
.quantum-drop-down-menu__top-nav-link:hover {
  background: transparent;
}
a.lang.quantum-drop-down-menu__top-nav-link:hover {
  background: transparent;
}
#top-header
  > div
  > div
  > div
  > div.quantum-header__right
  > div.quantum-header__menu
  > nav
  > ul.quantum-drop-down-menu__list {
  display: none;
}
img {
  max-width: 100%;
  height: auto;
}
.f-note {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1rem;
  line-height: 1.5;
  color: #00619d !important;
}
.title span.big-text {
  font-family: "Montserrat";
  font-style: normal;
  font-weight: 700;
  font-size: 6rem;
  line-height: 1;
  color: #eb2244;
}
#slider-home .field-slideimage {
  max-width: 400px;
  width: 100%;
}
#slider-home .slide-info {
  width: 67%;
  height: auto;
  min-height: auto !important;
}
p.blue-text strong {
  font-weight: 600;
}
.dor.line.title-flex {
  margin-bottom: 3rem;
}
.dor.line.title-flex::before {
  margin: 0.8rem 1rem 0.8rem 0;
}
.dor.line.title-flex p {
  padding: 0;
  line-height: 1.7;
}
.median-time {
  font-family: "Montserrat";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1;
  text-align: center;
  color: #1f5680;
  padding: 1.3rem;
  max-width: 1140px;
  background: #ebf6f5;
  margin: 0px auto 2rem;
  border-radius: 30px;
}
.btn-group {
  display: flex;
  justify-content: space-evenly;
  max-width: 520px;
  margin: 0 auto;
}
.btn-group.btn-group-fr {
  max-width: 580px;
}
.bttn {
  background: #1e5680;
  text-align: center;
  color: #fff;
  display: inline-block;
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 700;
  font-size: 1.125rem;
  line-height: 1.1;
  padding: 0.6rem 2.4rem;
  border-radius: 0;
  cursor: pointer;
  border: none;
  margin: 0 0.5rem;
  text-decoration: none;
}
.visit-pubMed.bttn a {
  color: #fff;
  text-decoration: none;
}
footer#footer .field-link {
  border-bottom: 1px solid #fff;
}
.learn-about-codebreak {
  margin-top: 2rem;
  text-align: center;
  margin-bottom: 1rem;
}
.visit-pubMed {
  margin-bottom: 3rem;
}
.ref-sec p {
  color: #143757;
  line-height: 2;
}
.quantum-modal__dialog.quantum-modal__dialog--fit-content {
  max-width: 1200px;
}
.study-popup-img {
  margin: 3rem 0 2rem;
}
.title-icon {
  display: flex;
  margin-right: 1rem;
}
.popup-title {
  display: flex;
  align-content: center;
}
.title-icon {
  display: flex;
  margin-right: 2rem;
  width: 100px;
  height: 100px;
}
.popup-title-text {
  width: 90%;
}
.patient-td {
  font-family: "Montserrat";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #000000;
}
.patient-td.first-clounm {
  font-weight: 700;
  width: 40%;
}
.patient-dem-table {
  margin: 2rem;
  position: relative;
}
.patient-tr {
  display: flex;
}
.patient-td {
  width: 60%;
  padding: 0.5rem 2rem;
}
.quantum-modal__dialog,
.quantum-modal .quantum-modal__dialog {
  height: auto;
  margin: auto;
  bottom: auto;
  top: 70px;
  position: absolute;
  left: 0;
  right: 0;
}
.quantum-modal.quantum-modal--visible {
  overflow-y: scroll;
}
div#isi-popup
  .quantum-modal__dialog.quantum-modal__dialog--fit-content.quantum-modal__dialog--fit-full {
  padding: 3rem 2rem 2rem;
}
p.primary,
footer#footer .isi-ul ul li,
.isi-main-page ul li {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
  padding: 0.5rem 0;
}
footer#footer .isi-ul ul li {
  padding: 0.2rem 0;
}
footer#footer .isi-text {
  padding: 0.3rem 0.8rem;
  border: 2px solid #1e5680;
  margin: 2rem 0 0;
}
footer#footer .isi-ul ul,
.isi-main-page ul {
  display: block;
  list-style: disc;
  margin: 0 1.8rem;
}
p.primary a {
  color: #1e5680;
  text-decoration: underline;
  word-wrap: break-word;
}
.isi-continue {
  margin-top: 1rem;
}
.isi-continue .bttn {
  font-weight: 500 !important;
  margin: 0;
}
.patient-dem-table::before,
.safety-tabf-table::before {
  content: "";
  width: 20px;
  height: 100%;
  background: #73bca8;
  position: absolute;
  border-radius: 20px 0 0 20px;
  left: -20px;
}
.patient-tr:nth-of-type(odd) {
  background: rgba(0, 0, 0, 0.02);
}
.tabs .component-content .tabs-inner .tabs-container .tab {
  padding: 2rem 0 0;
}
.tabs .component-content .tabs-inner .tabs-heading li {
  width: 50%;
  background: #1e5680;
  border-radius: 1rem 1rem 0 0;
  border: none;
}
.tabs .component-content .tabs-inner .tabs-heading li:last-child,
.tabs .component-content .tabs-inner .tabs-heading li:first-child {
  border-radius: 1rem 1rem 0 0;
  border: none;
}
.tabs .component-content .tabs-inner .tabs-heading li:last-child {
  margin-left: 0.3rem;
}
.tabs .component-content .tabs-inner .tabs-container {
  border: none;
  background: #fff;
}
.tabs .component-content .tabs-inner .tabs-heading li:first-child {
  margin-right: 0.3rem;
}
.tabs .component-content .tabs-inner .tabs-heading li.active,
.tabs .component-content .tabs-inner .tabs-heading li.active:hover {
  background: #0b3657;
  color: #fff;
  border: none;
  border-radius: 1rem 1rem 0 0;
  border-radius: 1rem 1rem 0 0;
}
.tabs .component-content .tabs-inner .tabs-heading li:hover {
  background: #0b3657;
  border: none;
}

.tabs .component-content .tabs-inner .tabs-heading li > div {
  color: #fff;
  white-space: initial;
}
.tabs .component-content .tabs-inner .tabs-heading li > div .field-heading {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 700;
  font-size: 1rem;
  line-height: 1.3;
  text-align: center;
  color: #ffffff;
}
.tabs .component-content .tabs-inner .tabs-heading {
  border-bottom: 10px solid #0b3657;
}
ul.tabs-heading::after {
  content: "";
  width: 100%;
  position: absolute;
  left: -100%;
  background: #0b3657;
  height: 10px;
  bottom: -10px;
}
ul.tabs-heading::before {
  content: "";
  width: 100%;
  position: absolute;
  right: -100%;
  background: #0b3657;
  height: 10px;
  bottom: -10px;
}
/* .tabs .component-content .tabs-inner .tabs-heading{
    padding: 0 4rem;
} */
.safety-tabf-table {
  margin: 0 0 2rem 1.25rem;
  position: relative;
}
.safety-tabf-table-main {
  margin: 2rem 0;
  position: relative;
}
.tabf-table-td,
.tabf-top-table-td {
  width: 33.33%;
  padding: 1rem;
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.25rem;
  line-height: 1.3;
  color: #1e5680;
}
.tabf-table-tr.tr-no-border {
  border: none;
}
.tabf-table-tr {
  display: flex;
  border-bottom: 3px solid rgba(0, 0, 0, 0.04);
}
.tabf-table-td.tabf-table-td-head {
  font-weight: bold;
  background: #fafafa;
  width: 100%;
  border: none;
}
.tabf-top-table-td {
  text-align: center;
  font-weight: 700;
}
.tabf-top-table-td.tabf-top-table-head {
  width: 66.66%;
  text-align: center;
}
.tabf-top-table-td.dblue {
  background: #0b3657;
  color: #fff;
}
.tabf-top-table-td.tabf-top-table-head {
  border: 2px solid #73bca8;
}
.tabf-top-table-td.lblue {
  background: #1e5680;
  color: #fff;
}
.tabf-table-td:nth-child(2),
.tabf-table-td:nth-child(3) {
  text-align: center;
}
.tabf-top-table-tr {
  display: flex;
  justify-content: flex-end;
}
.safety-tab2 ul {
  list-style: disc;
  margin-left: 2rem;
}
.safety-tab2 ul li {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
  padding: 0.4rem 0;
}

.tab3-table1 ul {
  margin: 1.3rem;
  list-style: disc;
}
ul.tab3-table-ul-child {
  margin: 0 2rem;
}

.tab3-table1 ul li {
  font-family: "Montserrat";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.6;
  color: #1e5680;
}
.safety-tab2 {
  margin-bottom: 2rem;
}
.tab3-table {
  padding: 0 1rem;
}
.safety-tab3 {
  display: flex;
}
.tab3-table1 {
  background: rgba(0, 0, 0, 0.04);
  margin-right: 0.8rem;
  width: 50%;
}

.tab3-table1-title {
  background: #1e5680;
}

.tab3-table1-title p.blue-text {
  color: #fff;
  font-size: 1rem;
  padding-left: 1.2rem;
  font-weight: 600;
}
.tab3-table.table-3 p.blue-text {
  font-size: 1.125rem;
  font-family: "Montserrat";
}
div#slider-home {
  padding: 0;
  background: #f1f8f6;
  margin: 3rem 0;
}
.tab3-table-titel {
  margin-top: 2rem;
}

.dosing-c-border {
  display: flex;
  justify-content: flex-end;
  margin: 0 auto 3rem;
  position: relative;
}
h4.dosing-kras-title.title {
  max-width: 720px;
}
.dosing-kras {
  padding: 1.5rem 2rem;
  border-top: 10px solid #eb2244;
  border-left: 10px solid #eb2244;
  border-bottom: 10px solid #eb2244;
  border-radius: 30px 0 0 30px;
}
.dosing-kras:after {
  content: "";
  height: 10px;
  position: absolute;
  width: 100%;
  background: #eb2244;
  bottom: 0;
}
.dosing-kras::before {
  content: "";
  height: 10px;
  position: absolute;
  width: 100%;
  background: #eb2244;
  top: 0;
}
.recommended ul {
  margin: 0;
  list-style: disc;
  padding: 0 2rem;
}
.recommended ul li {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.4;
  color: #1e5680;
  padding: 0 0 0.5rem 0;
}
.how-to-take-lumakras {
  display: flex;
  justify-content: space-between;
  margin: 3rem 0;
}
.how-to-take-lumakras-cnt {
  width: 26%;
}
.how-to-take-lumakras-icon img {
  margin: 0 auto;
}
.how-to-take-lumakras-icon {
  display: flex;
  align-items: center;
  position: relative;
  padding-bottom: 2rem;
}
.how-to-take-lumakras-icon::after {
  content: "";
  height: 10px;
  width: 100%;
  background: #eb2244;
  position: absolute;
  left: 0;
  bottom: 0;
  border-radius: 10px;
}
.how-to-take-lumakras-des a {
  text-decoration: underline;
  color: #1e5680;
}
div#dosing-confirm-presence_ {
  position: relative;
  overflow: hidden;
  padding: 0;
}
div#dosing-page,
#widget-1 {
  padding: 0;
}
.line-height,
.line-height ul li {
  line-height: 2 !important;
}
.isi-main-page.open-sens p,
.isi-main-page.open-sens ul li {
  font-family: "Open Sans" !important;
}
.img-part2 img {
  margin-top: 3rem;
}
.how-to-take-lumakras-des ul,
.victory-program-gray-box ul {
  list-style: disc;
  margin-left: 2rem;
}
p.primary.blue-title2-padding.padding-top {
  padding-top: 2rem;
}
.title.padding-top-b,
.padding-top-b {
  padding: 1.2rem 0;
}
.how-to-take-lumakras-des ul li,
.victory-program-gray-box ul li {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.5;
  color: #1e5680;
}
.title a {
  color: #fff;
}
.title.victory-program-title a {
  color: inherit;
  text-decoration: none;
}
.victory-program-gray-box ul li {
  font-size: 1.125rem;
}
.victory-program-gray-box p.blue-text {
  font-weight: 600;
}
.victory-program.line.title-flex {
  margin: 1rem 0;
}
.dose-modification-recommended,
.dose-modification-f-note {
  margin-top: 5rem;
}
.dose-modification-f-note p.f-note {
  padding: 1rem 0;
}
.patients-difficulty-icon {
  width: 100px;
  margin: 1.5rem 2rem 1.5rem 0;
}
.patients-difficulty-list {
  display: flex;
}
.alternative-dosing-method {
  width: 75%;
}
.alternative-dosing-method.line::before {
  min-height: 90px;
}
.alternative-dosing-method.line.title-flex {
  align-items: center;
}
.patients-difficulty {
  margin: 2rem 0;
}
#dosing-bottom-box {
  padding: 1rem 0;
  background: #275776;
  margin-top: 4rem;
}
#dosing-bottom-box .title {
  color: #fff;
  padding: 2rem 0;
}
a.w-bttn.bttn {
  background: #fff;
  color: #1f5680;
  display: inline-block;
  margin: 0 1rem 1.5rem 0;
  text-decoration: none;
}
.drug-interactions-tr {
  display: flex;
  border-bottom: 3px solid rgba(0, 0, 0, 0.2);
}
.drug-interactions-td {
  width: 100%;
  flex: 0 auto;
}
.drug-interactions-td.gray-bg.drk {
  width: 44%;
}
.drug-interactions-top-title {
  margin: 0px 8rem 3rem;
}
p.drug-interactions-title {
  font-weight: 700;
}
.drug-interactions-td.gray-bg.drk {
  background: #d9d9d9;
}
.gray-bg.round-corner {
  padding: 2rem 4rem;
  border-radius: 40px;
}
.title.victory-program-title span {
  font-weight: 400;
}
.isi-main-page .isi-text {
  border: 2px solid #1e5680;
  padding: 0.8rem 1rem;
  margin: 1rem 0 2rem;
}
ul#isi-ul {
  margin: 0 1.8rem 0rem;
}
ul#isi-ul li,
ul#isi-ul-box li {
  padding: 0;
}
p.primary.isi-blod {
  font-weight: 700;
}
ul#isi-ul-box {
  margin: 0 2.5rem;
}
.isi-main-page,
.references-page {
  margin-bottom: 5rem;
}
.references-page ol {
  list-style: auto;
  margin-left: 2rem;
}
.references-page ol li {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
  padding: 0.3rem 0;
}
.pai-graph-table p.f-note {
  margin: 2rem 0 0;
}
.nowrap {
  white-space: nowrap;
}
.quantum-banner__image-area,
.sp-only {
  display: none;
}

/* a.quantum-drop-down-menu__link.active {
    background: red;
} */

#patient-resources .download-section {
  padding: 1.5rem 0;
}
.download-des-text {
  width: 100%;
}
#footer #cnt-custom {
  padding: 0;
}
.moa-text ul {
  list-style: disc;
  margin-left: 1.5rem;
}
.moa-text ul li {
  width: 300px;
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.2;
  color: #55575b;
  padding: 0.2rem 0;
}
.moa-sec1 {
  margin-bottom: 4rem;
}
.moa-text ul ul {
  margin-left: 2.2rem;
  margin-top: 0.5rem;
}

/*admin-page styles*/

.admin-page p.primary {
  font-family: "Roboto";
  font-size: 1rem;
  line-height: 1.1;
}
.administration ul#isi-ul li {
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.1;
  color: #1e5680;
  padding: 0.5rem 0;
  font-family: "Roboto";
  list-style: disc;
}
.administration ul.order-list li {
  margin-left: 39px;
}
.administration span.bold-text {
  font-weight: 700;
}
.administration-program-gray-box p.blue-text {
  font-weight: 700;
  color: #000;
}
.administration-program-gray-box ul {
  list-style: disc;
  margin-left: 1.5rem;
}
.administration-program-gray-box ul li {
  font-size: 1.125rem;
  line-height: 1.5;
  font-family: "Roboto";
  font-weight: 400;
  color: #000;
  padding: 0.3rem 0;
}
div#orange-bottom-box {
  margin-top: 4rem;
  background-color: #ffa400;
}
.bg-clr.administration-page {
  background-color: unset;
}

/*starting*/
ul.quantum-drop-down-menu__menu
  li.quantum-drop-down-menu__menu-list-item
  a.quantum-drop-down-menu__menu-link:first-child.super-sub-menu:after {
  content: "®";
  position: relative;
  top: -7px;
  font-size: 10px;
  left: -3px;
}
ul.quantum-drop-down-menu__menu
  li.quantum-drop-down-menu__menu-list-item
  a.quantum-drop-down-menu__menu-link:first-child.super-sub-menu-nxt:after {
  content: "MD";
  position: relative;
  top: -7px;
  font-size: 10px;
  left: -3px;
}
.starting-blincyto p.f-note {
  font-family: "Roboto";
  color: #275776;
  padding: 1rem 0;
}
.starting-blincyto-page p.blue-text {
  color: #275776;
}
.starting-blincyto-page .img-part img {
  margin: 3rem 0;
}

.bg-clr .title.victory-program-title {
  text-align: center;
  justify-content: center;
  margin: 0 auto;
  max-width: 64%;
  padding-right: 0;
  color: #000;
  font-family: "Roboto";
}
.bg-clr {
  background-color: #ffa400;
  padding: 21px;
  /* margin-bottom: 20px; */
}
.title.main-text {
  text-align: center;
  line-height: 1.5;
}
a.download-pdf-lang.dwn-bttn.pub-med {
  padding: 0.8rem 5rem;
  margin-left: 0;
}
p.small-txt {
  font-size: 1rem;
  padding: 0;
}
.orange-line {
  border-bottom: 3px solid #ffa400;
  margin: 2rem 0;
}

.field-heading:after {
  color: transparent;
  background-position: center;
  background-size: contain;
  background-repeat: no-repeat;
  font-size: 2.2rem;
  content: "";
  position: absolute;
  right: 6px;
  top: 13px;
  bottom: 0;
  width: 24px;
  height: 24px;
  background-image: url(/~/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Blincyto/images/dosing-and-administration/plus-image);
}
.field-heading {
  border-top: 1px solid #bec3c5;
  line-height: 1.6;
  padding: 0.8rem 2rem 12px 0;
  position: relative;
  cursor: pointer;
}

li.item.active .field-heading:after {
  background-image: url(/~/media/Themes/Amgen/Amgencompass-ca/Amgencompass-Blincyto/images/dosing-and-administration/minus-image);
}
.pai-graph {
  margin-top: 3rem;
}
.pai-graph-title {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 700;
  font-size: 1.5rem;
  line-height: 1.1;
  text-align: center;
  color: #275776;
  margin-bottom: 1rem;
}
.pai-graph-table {
  margin-top: 5rem;
}
.pai-graph-content {
  display: flex;
  justify-content: space-between;
}
.Send-to-patient.dwn-bttn.model-pop-up-open {
  display: inline-block;
  margin: 4rem 0 0;
}
.dwn-bttn.model-pop-up-open {
  opacity: 1 !important;
}
.dwn-bttn.model-pop-up-open.study-design-btn.btn-align-left {
  margin: 0;
}
.pai-graph-img1 {
  margin-right: 3rem;
}
.sub-title {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.3;
  color: #1e5680;
  margin-top: 0.6rem;
}
.popup-des .f-note {
  padding: 1rem 0;
}
#tower-trial-tab .field-heading {
  border: none;
}
#tower-trial-tab .field-heading:after {
  content: none;
}
.blue-title2 {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.2;
  color: #275776;
}
.blue-title2-padding {
  padding: 1rem 0 2rem;
}
.bttn {
  border: 0px !important;
}
.blue-title3 {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 2.25rem;
  line-height: 1.2;
  color: #1e5680;
}
.title.graph-title {
  text-align: center;
  margin: 4rem 0 0;
}
.bottom-line {
  border-bottom: 5px solid #ffa400;
  padding-bottom: 0.7rem;
}
.tab-cnt {
  margin: 2rem 0 0;
}
.graph-img {
  margin-bottom: 3rem;
}
p.title.blue-title2-padding.align-center {
  margin: 0 auto;
  max-width: 1040px;
}
.study-design-btn {
  display: table;
  margin: 0 auto;
  /* max-width: 220px; */
}
.study-design-yellow-bg {
  background: #ffa400;
  padding: 1rem;
  margin-bottom: 2rem;
  -webkit-box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
  -moz-box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
  box-shadow: 0px 3px 3px 0px rgba(0, 0, 0, 0.27);
}

.tab-full-w-color-box::after {
  content: "";
  background: #275776;
  position: absolute;
  right: -100%;
  width: 100%;
  top: 0;
  bottom: 0;
}
.tab-full-w-color-box::before {
  content: "";
  background: #275776;
  position: absolute;
  left: -100%;
  width: 100%;
  top: 0;
  bottom: 0;
}
.study-design-f-note {
  margin: 4rem 0 0;
}
.blue-title3-padding {
  max-width: 901px;
  margin: 0 auto;
}
.margin-bottom {
  margin-bottom: 2rem;
}
.component.container.tab-content-1,
.component.container.tab-content-2 {
  max-width: 100%;
  padding: 0;
}
.graph-content {
  display: flex;
  align-items: center;
}
.align-center {
  text-align: center;
}
.accordion .field-heading {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  color: #275776;
}
.accordion .field-content {
  margin-bottom: 1rem;
}
.accordion-ul ul {
  list-style: disc;
  margin: 0 2rem;
  padding: 0px;
}
.icon-text ol {
  margin-left: 2.3rem;
  list-style: decimal;
}
.accordion-ul ul li,
.accordion .field-content p,
.icon-text ol li {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 300;
  font-size: 1.125rem;
  line-height: 1.3;
  color: #212426;
  padding: 0.5rem 0;
}
.acc-img {
  margin: 2rem 0;
}
strong {
  font-weight: 700;
}
.icons {
  display: flex;
  align-items: center;
  margin-bottom: 2rem;
}
.icon {
  flex: 0 0 100px;
}
.icon-text {
  flex: 0 0 88%;
}
.icon.icon-tyle2 {
  flex: 0 0 200px;
}
.icon-text.icon-text2 {
  flex: 0 0 80%;
}
:lang(en) .english-lang .lang-select,
:lang(fr) .french-lang .lang-select {
  text-decoration: underline !important;
}
.study-design-p,
.accordion .field-content .study-design-yellow-bg p {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.2;
  color: #000000;
}
.inner-page-banner .quantum-banner__inner {
  background: #275776;
}
.acc-td-des ul {
  list-style: disc;
  margin-left: 1.5rem;
}
.td-head,
.acc-td-des,
.acc-td-des ul li {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 500;
  font-size: 1.5rem;
  line-height: 1.2;
  color: #ffffff;
}
.acc-img .patient-group-td {
  border-right: 1px solid #275776;
  border-left: 1px solid #275776;
}
.acc-img .patient-group-tr {
  border-bottom: 2px solid #275776;
}
.acc-img .patient-group-table {
  border-left: 1px solid #275776;
  border-right: 1px solid #275776;
}
.acc-td-des,
.acc-td-des ul li {
  color: #275776;
}
.acc-td-des ul li {
  padding: 0 0 0.7rem 0;
}
.acc-td-col4 {
  flex: 0 0 90.6%;
}
.acc-td-head {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.5rem;
  line-height: 1.2;
  color: #ffffff;
}

.td-col1 {
  flex: 0 0 300px;
}
.td-col1 {
  flex: 0 0 346px;
}
.patient-group-tr {
  border-bottom: 2px solid #ffffff;
}
.td-light-gray {
  background: #ccd1d6;
}
.td-light-gray2 {
  background: #e7e9ec;
}
.td-col2 {
  flex: 0 0 72%;
}
.patient-group-td {
  padding: 0.6rem 1rem;
  border-right: 2px solid #fff;
}
.td-des {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.3;
  color: #000;
}
.tr-blue {
  background: #275776;
}
.patient-group-tr {
  display: flex;
}
.acc-img .patient-group-tr,
.yellow-tr,
.pai-graph-tr {
  display: table-row;
}
.pai-graph-td,
.pai-graph-table-title {
  padding: 0.5rem;
  border: 1px solid #fff;
}
.acc-td-col1,
.acc-td-col2,
.acc-td-col3,
.yellow-td,
.pai-graph-td {
  display: table-cell;
}
.patient-group-tr.merge-rows {
  display: table;
  width: 100%;
  border-top: 2px solid #275776;
}
.yellow-tr-merge-cell,
.pai-graph-table2 {
  display: table;
  width: 100%;
}
.yellow-table-head {
  font-family: "Roboto";
  font-style: normal;
  font-weight: 700;
  font-size: 1.125rem;
  line-height: 1.2;
  padding: 1rem;
  color: #fff;
  text-align: center;
}
.yellow-table {
  /* display: table; */
  width: 100%;
}
.yellow-col1 {
  width: 48%;
}
.yellow-td-bg {
  background: #ffa400;
}
.yellow-col2 {
  width: 15%;
}
.acc-td-col1 {
  width: 16%;
}
.graph-group-img {
  display: flex;
  justify-content: space-between;
}
footer#footer .row.component.column-splitter {
  align-items: flex-end;
}
.graph-img.graph-img-m0 {
  margin-bottom: 1rem;
}
div#dosing-bottom-box a {
  text-decoration: none;
  border-bottom: 3px solid #fff;
}
textarea,
input[type="text"],
input[type="button"],
input[type="submit"],
button {
  -webkit-appearance: none;
  border-radius: 0;
}
.patient-group-table.preparation-table {
  display: table;
  width: 100%;
  border-bottom: 1px solid #275776;
}
.patient-group-table.preparation-table .patient-group-td,
.patient-group-table.preparation-table .acc-td-head {
  border: 1px solid #275776;
  font-size: 1.125rem;
}

li.quantum-drop-down-menu__top-nav-list-item.home-icon a::before {
  content: "\f015";
  display: inline-block;
  font: normal normal normal 16px/1 FontAwesome;
  font-size: inherit;
  text-rendering: auto;
  -webkit-font-smoothing: antialiased;
  color: #fff;
  position: absolute;
  top: 9px;
  font-family: "FontAwesome";
  font-size: 1.2rem;
  left: 18px;
}
li.quantum-drop-down-menu__top-nav-list-item.home-icon span {
  visibility: hidden;
}
li.quantum-drop-down-menu__top-nav-list-item.home-icon {
  position: relative;
}
div#obu-external-link {
  display: none;
  visibility: visible;
  opacity: 1;
  z-index: 999;
}
#obu-external-link
  button.quantum-button.quantum-button--tertiary.quantum-modal__close.quantum-button--icon-only,
#blincyto-isi-popup
  button.quantum-button.quantum-button--tertiary.quantum-modal__close.quantum-button--icon-only {
  display: none;
}
button.blue-btn {
  border: none;
  padding: 0.5rem 1.5rem;
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 600;
  font-size: 1.125rem;
  line-height: 1.1;
  background: #1e5680;
  text-align: center;
  color: #fff;
  margin-top: 1.5rem;
  margin-right: 1rem;
  cursor: pointer;
}
.popup h2,
.content {
  font-family: "Open Sans";
  font-style: normal;
  font-weight: 400;
  font-size: 1.125rem;
  line-height: 1.5;
  color: #1e5680;
}
.patient-group-td.td-head.td-col1.align-center.tr-blue.text-middle {
  display: flex;
  align-items: center;
  justify-content: center;
  font-weight: 400;
}
.acc-img.img-center img {
  margin: 0 auto;
  display: block;
}
.download-dropdown.margin-top {
  margin-top: 3rem;
}
.download-dropdown label {
  font-size: 0;
  height: 0;
  display: block;
}
.bttn.btn-rsc {
  font-weight: 600;
  font-family: "Roboto";
  display: flex;
  padding: 0.8rem 5rem;
  font-size: 1rem;
}

/* pointer event none for download btn  */
.pointnone {
  pointer-events: none;
}

@media screen and (min-width: 576px) {
  #acc-td-col1 {
    width: 203px;
  }
  #acc-td-col2 {
    width: 42%;
  }
  #acc-td-col3 {
    width: 42%;
  }
  .inner-page-banner .quantum-banner__inner {
    display: block;

    height: auto;
  }
  .quantum-header__left {
    padding-left: 15px;
  }
  .quantum-banner__inner:before {
    display: none;
  }
}

@media screen and (min-width: 992px) {
  .quantum-drop-down-menu__link {
    padding: 16px;
  }
  .tabs .component-content .tabs-inner .tabs-heading li.active,
  .tabs .component-content .tabs-inner .tabs-heading li.active:hover {
    border-top: 2px solid #ffa400;
    border-right: 2px solid #ffa400;
    border-left: 2px solid #ffa400;
  }
  ul.tabs-heading::after,
  ul.tabs-heading::before {
    border-top: 2px solid #ffa400;
  }
  #home .quantum-banner--multiple-background-images .quantum-banner__inner {
    height: 720px;
  }
  .quantum-header__logo {
    /* max-height: 80px; */
  }
  .dosing-bottom-dwn-box {
    padding: 0 1rem;
  }
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    padding: 3rem;
  }
  .title.victory-program-title {
    padding-right: 7rem;
  }
  .quantum-drop-down-menu__list {
    max-width: 940px;
  }
  .quantum-drop-down-menu__menu-link {
    padding: 0.6rem 1rem;
  }
  #header
    > div
    > div.quantum-header__right
    > div.quantum-header__menu
    > nav
    > ul.quantum-drop-down-menu__list
    li:last-child
    a {
    padding-right: 0px;
  }
  .title.safety-tab-title {
    margin-right: 4rem;
  }
}

@media screen and (min-width: 992px) {
  .download-dropdown.margin-top {
    margin-top: 2rem;
  }
  .inner-page-banner .quantum-banner__text {
    max-width: 1260px;
    padding: 0 1rem;
  }
  div#patient-resources {
    padding: 0;
  }
  .slide .component-content {
    display: flex;
    align-items: center;
  }
  .inner-page-banner .quantum-banner__inner {
    padding: 4% 0;
    height: auto;
  }
  .quantum-drop-down-menu__menu {
    -webkit-box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    -moz-box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    box-shadow: inset 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    border-bottom: 5px solid #1f5680;
  }
  .quantum-drop-down-menu__menu {
    padding: 0;
    background: #e5e5e5;
    width: 315px;
    white-space: initial;
  }
  .quantum-drop-down-menu__menu-link {
    padding: 1rem 0;
    margin: 0 2rem;
    border-bottom: 1px solid #c4c4c4;
    white-space: inherit;
    font-size: 1rem;
    font-weight: 400;
  }
  .quantum-drop-down-menu__menu-link:hover,
  a.quantum-drop-down-menu__menu-link.active {
    background: transparent;
    font-weight: 700;
  }

  li.quantum-drop-down-menu__menu-list-item:last-child
    a.quantum-drop-down-menu__menu-link {
    border: none;
  }
  .quantum-drop-down-menu__list-item--dropdown-visible
    .quantum-drop-down-menu__link,
  .quantum-drop-down-menu__list-item:hover > .quantum-drop-down-menu__link,
  .quantum-drop-down-menu__link:hover,
  a.quantum-drop-down-menu__link.active {
    background: #e5e5e5;
  }
}
@media screen and (min-width: 1300px) {
  .inner-page-banner .quantum-banner__text {
    padding: 0;
  }
}
@media screen and (max-width: 1200px) {
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    margin: 0 1rem;
  }
  .td-col2 {
    flex: 0 0 70%;
  }
  .td-col1 {
    flex: 0 0 30%;
  }
  #obu-external-link .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    margin: 0 auto;
  }
}
@media screen and (max-width: 1024px) {
  .quantum-drop-down-menu__link,
  .quantum-drop-down-menu__menu-link {
    font-size: 1rem;
    padding: 1rem 0.2rem;
  }
  div#moa-md-right-cnt,
  div#moa-md-right-img {
    padding: 0 15px;
  }
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    margin: 0 1rem;
  }
}
@media screen and (max-width: 991px) {
  .quantum-drop-down-menu__link,
  .quantum-drop-down-menu__menu-link {
    font-size: 1rem;
    padding: 1rem;
  }
  svg.quantum-icon.quantum-button__icon.desktop-break {
    display: none;
  }
  .quantum-header__menu {
    right: 0;
  }
  #top-header .quantum-header__menu {
    display: block;
    position: relative;
    width: auto;
    top: 7px;
    right: 0;
    background: transparent;
  }
  #top-header nav.quantum-drop-down-menu {
    border: none;
    background: transparent;
    box-shadow: none;
    margin: 1rem;
  }
  #slider-home .field-slideimage {
    max-width: 400px;
  }
  .slide1-logo {
    margin-top: 1rem;
    max-width: 190px;
  }
  a.download-pdf-lang.dwn-bttn {
    padding: 0.8rem 3rem;
  }
  .quantum-header__logo {
    padding: 5px 5px 5px 0;
  }
  #dosing-bottom-box {
    padding: 1rem;
  }
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    height: 90%;
  }
  #obu-external-link .quantum-modal__dialog,
  #obu-external-link .quantum-modal .quantum-modal__dialog {
    height: auto;
  }
  .select.dwn-pdf {
    border-radius: 0;
    font-size: 1rem;
    height: 40px;
  }
}
@media screen and (max-width: 768px) {
  #moa-md-right-img > div {
    width: 300px;
  }
  h1.quantum-banner__title {
    font-size: 2.25rem;
    line-height: 1.3;
  }
  .quantum-header__left {
    width: 110px;
  }
  #home
    .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {
    height: 40px;
  }
  #home h1.quantum-banner__title {
    padding: 0rem 1rem 5rem;
  }
  .slide-title,
  p.blue-text,
  .median-time,
  .how-to-take-lumakras-des ul li,
  .victory-program-gray-box ul li,
  .recommended ul li,
  .blue-title2,
  .pai-graph-title,
  .moa-text ul li,
  .study-design-p,
  .accordion-ul ul li,
  .accordion .field-content .study-design-yellow-bg p,
  .title.graph-title,
  .accordion .field-heading,
  .td-head,
  .acc-td-head,
  .popup h2,
  .content {
    font-size: 1.2rem;
  }
  .title,
  h1.quantum-banner__title,
  .blue-title3,
  .home-banner-text,
  #home .quantum-banner__title {
    font-size: 1.5rem;
  }
  .dor.line.title-flex p {
    line-height: 1.5;
  }
  .quantum-banner--multiple-background-images .quantum-banner__inner {
    padding: 5% 1rem;
  }
  .tabs .component-content .tabs-inner .tabs-heading,
  .tabs .component-content .tabs-inner .tabs-container .tab,
  .tabs-container .component.content.col-12 {
    padding: 0;
  }
  .tabs .component-content .tabs-inner .tabs-heading {
    white-space: initial;
  }
  .field-content,
  .title.graph-title {
    margin-top: 2rem;
  }
  .tabf-table-td,
  .tabf-top-table-td,
  .td-des,
  .td-head,
  .acc-td-des,
  .acc-td-des ul li {
    font-size: 1rem;
  }
  .tabf-table-tr {
    border-bottom: 2px solid rgba(0, 0, 0, 0.04);
  }
  .quantum-header__menu {
    right: 0;
  }
  #top-header nav.quantum-drop-down-menu {
    margin: 0.2rem 0;
  }
  li.quantum-drop-down-menu__top-nav-list-item a {
    font-weight: 600;
  }
  .quantum-header__menu {
    max-width: 768px;
  }
  li.quantum-drop-down-menu__list-item {
    border-bottom: 2px solid rgba(0, 0, 0, 0.04);
  }
  .callout {
    margin-right: 0;
  }
  .how-to-take-lumakras {
    flex-wrap: wrap;
  }
  .how-to-take-lumakras-cnt {
    width: 100%;
    margin: 0rem 0 3rem;
  }
  .dosing-kras::before,
  .dosing-kras:after {
    height: 5px;
  }
  .dosing-kras {
    padding: 0.5rem 1rem;
    border-top: 5px solid #eb2244;
    border-left: 5px solid #eb2244;
    border-bottom: 5px solid #eb2244;
    border-radius: 20px 0 0 20px;
    max-width: 400px;
    width: 70%;
  }
  .drug-interactions-top-title {
    margin: 0px 0rem 2rem;
  }
  .drug-interactions-td.gray-bg.drk {
    width: 82%;
  }
  .dose-modification-recommended,
  .dose-modification-f-note {
    margin-top: 3rem;
  }
  .alternative-dosing-method.line::before {
    min-height: 90px;
    height: 81%;
  }
  .alternative-dosing-method {
    width: 90%;
  }
  h1.quantum-banner__title {
    padding: 0 1rem;
  }
  .model-popup-patient-resources {
    overflow: scroll;
  }
  form#patient-resources-obu-lmk {
    top: 0;
    left: 50%;
    transform: translate(-50%, 3%);
    width: 90%;
    padding: 1rem;
  }
  .pai-graph-content,
  .graph-content {
    display: block;
  }
  .pai-graph-img1 {
    margin: 0 auto;
    max-width: 370px;
  }
  .quantum-header__logo {
    padding: 0.23rem 0;
  }
  .quantum-banner,
  .moa-sec1,
  #dosing-bottom-box,
  .graph-img {
    margin-bottom: 2rem;
  }
  .pai-graph-table,
  .pai-graph-table,
  .graph-right-text,
  #dosing-bottom-box,
  .study-design-f-note {
    margin-top: 3rem;
  }
  .Send-to-patient.dwn-bttn.model-pop-up-open,
  .Send-to-patient.dwn-bttn.model-pop-up-open,
  .study-design-btn {
    margin: 2rem auto 0;
  }
  .patient-group-td {
    padding: 0.6rem;
  }
  /* .acc-td-col1 {
        flex: 0 0 78px;
    }
    .acc-img .patient-group-td {
        padding: 0.6rem;
    }
    .acc-td-des ul{
        margin-left: 0.8rem;
    }
    .acc-td-col2, .acc-td-col3 {
        flex: 0 0 39%;
    }
    .acc-td-col4 {
        flex: 0 0 78%;
    } */
}

@media screen and (max-width: 720px) {
  #home .quantum-banner__title {
    max-width: 310px;
  }
  :lang(fr) div#obu-external-link .quantum-modal__dialog {
    overflow: scroll;
    height: 80%;
  }
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    top: 50px;
  }
}
@media screen and (max-width: 640px) {
  #slider-home .field-slideimage,
  #slider-home .field-slideimage img {
    max-width: 100%;
    width: 100%;
  }

  #home h1.quantum-banner__title {
    background: rgb(0 0 0 / 61%);
    padding: 1rem;
  }
  .accordion .field-heading {
    padding-right: 2.2rem;
  }
  .icon {
    flex: 0 0 80px;
  }
  .icon-text {
    flex: 0 0 80%;
  }
  .icon.icon-tyle2 {
    flex: 0 0 160px;
  }
  .icon-text.icon-text2 {
    flex: 0 0 55%;
  }
  .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    height: 80%;
  }
  #obu-external-link .quantum-modal__dialog,
  #obu-external-link .quantum-modal .quantum-modal__dialog {
    height: auto;
  }
  .sp-only {
    display: block;
    padding: 1rem;
  }
  .pc-only,
  #footer-top .component-content ul li a::after,
  footer#footer ul li a::after {
    display: none;
  }
  #home
    .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {
    height: 34px;
  }
  .slide .component-content {
    display: flex;
    flex-wrap: wrap;
  }
  #slider-home .slide-info {
    width: 100%;
  }
  .carousel-inner .field-slidetext,
  #slider-home li.slide .component.content.col-12,
  .tabs .component-content .tabs-inner .tabs-heading li .component.content {
    padding: 0;
  }
  /* h1.quantum-banner__title {
        padding: 0rem 0rem 3rem;
    } */
  .bttn {
    width: 100%;
    margin: 0;
  }
  .study-design.bttn {
    margin-bottom: 1.5rem;
  }
  .learn-about-codebreak {
    margin-top: 1rem;
  }
  .popup-title {
    display: block;
  }
  .title-icon {
    margin-right: 0.5rem;
    width: 100px;
    height: 100px;
    margin: 0 auto 2rem;
  }
  .popup-title-text {
    width: 100%;
  }
  .quantum-modal__dialog {
    padding: 48px 1rem 24px;
  }
  .patient-td {
    padding: 0.5rem;
    font-size: 1rem;
  }
  .patient-dem-table {
    margin: 1rem 0 1rem 1rem;
  }
  .btn-group {
    display: block;
  }
  .tab3-table1 {
    width: 100%;
  }
  .safety-tab3 {
    display: block;
  }
  div#moa-md-sec,
  #cnt-custom {
    margin: 0 auto;
  }
  #dosing-bottom-box .title {
    padding: 1rem 0;
  }
  .gray-bg.round-corner {
    padding: 2rem 1rem;
    border-radius: 10px;
  }
  #footer-amgen-logo img {
    margin: 2rem auto;
    display: block;
  }
  #footer-top .component-content ul,
  footer#footer ul,
  .footer-logos,
  #footer-top .component-content {
    justify-content: center;
  }
  #footer-top .component-content .isi-ul ul,
  footer#footer .isi-ul ul {
    text-align: left;
  }
  footer#footer ul li a,
  #footer-top .component-content ul li a {
    font-size: 1rem;
    font-weight: 600;
  }
  .footer-content p {
    font-size: 1rem;
    text-align: center;
  }
  footer#footer {
    padding: 1rem 0 2rem;
  }
  #footer-top .component.link-list {
    order: 2;
    margin-bottom: 0.5rem;
  }

  .callout-img {
    width: 130px;
  }
  .tabs .component-content .tabs-inner .tabs-heading li.active,
  .tabs .component-content .tabs-inner .tabs-heading li.active:hover,
  .tabs .component-content .tabs-inner .tabs-heading li,
  .tabs .component-content .tabs-inner .tabs-heading li:last-child,
  .tabs .component-content .tabs-inner .tabs-heading li:first-child {
    border-radius: 0;
  }
  .tabs .component-content .tabs-inner .tabs-heading {
    flex-wrap: wrap;
  }
  .tabs .component-content .tabs-inner .tabs-heading li {
    width: 100%;
  }
  .tabs .component-content .tabs-inner .tabs-heading li:first-child,
  .tabs .component-content .tabs-inner .tabs-heading li:last-child {
    margin: 0.5rem 0 0;
  }
  ul.tabs-heading li {
    margin: 0.5rem 0 0;
  }
  .download-pdf-main,
  .download-dropdown {
    display: block;
  }
  .download-thumbnail {
    margin: auto auto 1rem;
    width: 60%;
  }
  select.dwn-pdf {
    max-width: 100%;
  }
  a.download-pdf-lang.dwn-bttn {
    padding: 1rem 0;
    text-align: center;
    margin: 1rem 0 0;
    display: block;
  }
  .download-btn-select-all .dwn-bttn {
    flex: 0 0 100%;
    margin: 0.3rem 0;
  }
  .download-btn-select-all {
    display: flex;
    flex-wrap: wrap;
  }
  .contacts-from-td {
    flex: 0 0 98%;
  }
  .td-col1,
  .td-col2 {
    flex: 0 0 50%;
  }
  .nowrap {
    white-space: break-spaces;
  }
  .victory-program #dosing-bottom-box .w-download-btn a,
  a.w-bttn.bttn {
    border-radius: 0;
    margin: 0.5rem 0;
  }
  a.w-bttn.bttn {
    margin: 0.5rem 0;
  }
  div#footer-bottom-top-logo {
    width: 100%;
  }
  #footer-top .component-content ul,
  footer#footer ul {
    display: block;
    text-align: center;
  }
  #footer-top .component-content ul {
    margin: 1rem 0 0;
  }
  footer#footer ul li a,
  #footer-top .component-content ul li a {
    padding: 0.5rem 0;
    display: block;
  }
  footer#footer .field-link {
    border-bottom: none;
  }
  #obu-external-link .quantum-modal__dialog,
  .quantum-modal .quantum-modal__dialog {
    margin: 0 1rem;
  }
}

@media screen and (max-width: 480px) {
  /* #home .quantum-banner--multiple-background-images .quantum-banner__inner {
        height: 180px;
    } */
  .callout-img {
    width: 100px;
  }
  a#lang-switch,
  a.lang.quantum-drop-down-menu__top-nav-link {
    width: 180px;
  }
  /* footer#footer ul li a, #footer-top .component-content ul li a {
        font-size: .8rem;

    } */
  .acc-td-col1 {
    width: 24%;
  }
  .acc-td-des ul {
    margin-left: 0.7rem;
  }
  .acc-td-des ul li {
    word-break: break-word;
  }
  .download-dropdown fieldset {
    display: block;
  }
  .subhead {
    display: block;
  }
}
@media screen and (max-width: 375px) {
  #home
    .quantum-banner.quantum-container--.quantum-banner--multiple-background-images::after {
    background: url(../images/home-page/banner-bottom-mobile.svg) no-repeat;
    width: 100%;
  }

  .callout-img {
    width: 80px;
  }
  .acc-td-col1 {
    width: 32%;
  }
}